Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCJ1B2)

Drug Name
MT-500 Drug Info
Synonyms
199864-87-4; RS-127445; 4-(4-fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2-amine; RS 127445; UNII-0JAU3P8OBM; MT 500; 0JAU3P8OBM; CHEMBL473186; C17H16FN3; RS-127445 HCl; 2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine; RS127445; 2-Pyrimidinamine, 4-(4-fluoro-1-naphthalenyl)-6-(1-methylethyl)-; RS-127,445; 4-(4-fluoronaphthalen-1-yl)-6-propan-2-ylpyrimidin-2-amine; AC1L52MZ; GTPL188; RS 127445 hydrochloride/; SCHEMBL375979; MolPort-021-804-999; ZZZQXCUPAJFVBN-UHFFFAOYSA-N; HMS3651H11; BCPP000085; BCP02714; ZINC3961115
Cross-matching ID
PubChem CID
196968
ChEBI ID
CHEMBL473186
CAS Number
CAS 199864-87-4
TTD Drug ID
D0QF4Z

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.41 0.00e+0 113/158 (71.52%) RPS4Y1;MRPL15;MRPS12;...
Oxidative phosphorylation 2.00 3.88e-3 93/133 (69.92%) ATP5PF;NDUFB7;ATP5ME;...
Steroid hormone biosynthesis 1.96 2.59e-3 43/61 (70.49%) HSD17B2;CYP11A1;HSD11B1;...
Thermogenesis 1.83 2.72e-2 173/232 (74.57%) GNAS;ATP5PF;CREB3L1;...
Base excision repair 1.79 2.95e-2 29/33 (87.88%) PCNA;POLD4;TDG;...
Ovarian steroidogenesis 1.78 2.59e-2 41/51 (80.39%) GNAS;HSD17B2;CYP11A1;...
DNA replication 1.78 2.33e-2 34/36 (94.44%) PCNA;POLD4;FEN1;...
Mismatch repair 1.73 3.40e-2 22/23 (95.65%) PCNA;POLD4;SSBP1;...
Pertussis -1.69 3.57e-2 64/76 (84.21%) CALML3;RHOA;IRF8;...
Chemokine signaling pathway -1.71 3.13e-2 163/192 (84.9%) MAPK3;GSK3B;HRAS;...
Amoebiasis -1.74 2.72e-2 99/102 (97.06%) FN1;CSF2;SERPINB3;...
T cell receptor signaling pathway -1.74 2.91e-2 93/104 (89.42%) PLCG1;CD28;GRAP2;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.74 3.11e-2 79/89 (88.76%) MAPK3;HRAS;CSNK2B;...
Cytokine-cytokine receptor interaction -1.76 2.70e-2 246/295 (83.39%) IL4R;IFNGR2;IL17A;...
NF-kappa B signaling pathway -1.82 1.61e-2 90/104 (86.54%) TNFRSF11A;CCL4;EDAR;...
Legionellosis -1.85 7.71e-3 51/57 (89.47%) NFKBIA;C3;HSPD1;...
NOD-like receptor signaling pathway -1.85 8.48e-3 145/181 (80.11%) CTSB;NFKBIA;RHOA;...
Mitophagy -1.86 9.42e-3 56/68 (82.35%) MFN2;CITED2;NRAS;...
Epithelial cell signaling in Helicobacter pylori infect... -1.86 9.08e-3 62/70 (88.57%) JAM2;TJP1;NFKBIA;...
Neutrophil extracellular trap formation -1.87 1.04e-2 101/189 (53.44%) HDAC6;MAPK3;ACTB;...
IL-17 signaling pathway -1.87 1.21e-2 84/94 (89.36%) HSP90AB1;CSF3;IL1B;...
Kaposi sarcoma-associated herpesvirus infection -1.89 1.45e-2 172/193 (89.12%) PDGFB;MAPK3;NFATC4;...
Viral protein interaction with cytokine and cytokine re... -1.91 0.00e+0 84/100 (84%) IL6;CXCL6;TNFSF10;...
Natural killer cell mediated cytotoxicity -1.94 0.00e+0 99/131 (75.57%) MAPK3;HRAS;SHC3;...
Rheumatoid arthritis -2.07 0.00e+0 78/93 (83.87%) ATP6V0B;CXCL12;ATP6V0D1;...
TNF signaling pathway -2.13 0.00e+0 103/112 (91.96%) JAG1;CSF2;TRAF3;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H