Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCJUI9)

Drug Name
GSK1070916A Drug Info
Cross-matching ID
PubChem CID
46885626
TTD Drug ID
D0P0HU

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Valine, leucine and isoleucine degradation 2.33 0.00e+0 42/48 (87.5%) ABAT;PCCA;HMGCL;...
Steroid biosynthesis 2.31 0.00e+0 19/20 (95%) SC5D;SQLE;FDFT1;...
Lysosome 2.03 0.00e+0 115/128 (89.84%) TPP1;NEU1;CTSL;...
Glyoxylate and dicarboxylate metabolism 2.03 0.00e+0 23/30 (76.67%) GRHPR;ACO2;PCCA;...
Selenocompound metabolism 1.97 3.17e-3 11/17 (64.71%) PAPSS2;CTH;KYAT3;...
Nicotinate and nicotinamide metabolism 1.97 2.64e-3 25/35 (71.43%) NNMT;QPRT;NMRK1;...
Arachidonic acid metabolism 1.97 2.27e-3 48/61 (78.69%) AKR1C3;PLAAT3;GPX2;...
Butanoate metabolism 1.84 4.96e-3 23/28 (82.14%) ABAT;HMGCL;HMGCS1;...
Other glycan degradation 1.82 4.40e-3 13/18 (72.22%) NEU1;MAN2C1;FUCA1;...
Alanine, aspartate and glutamate metabolism 1.78 1.03e-2 27/37 (72.97%) ASS1;ABAT;ASNS;...
Sulfur metabolism 1.78 9.37e-3 9/10 (90%) TST;PAPSS2;MPST;...
Propanoate metabolism 1.77 9.25e-3 30/34 (88.24%) ABAT;PCCA;PCCB;...
Oxidative phosphorylation 1.77 9.76e-3 93/133 (69.92%) ATP6V1C1;ATP6V1H;NDUFA10;...
Biosynthesis of unsaturated fatty acids 1.76 1.02e-2 21/27 (77.78%) SCD;HSD17B4;FADS1;...
Steroid hormone biosynthesis 1.70 1.85e-2 43/61 (70.49%) AKR1C3;CYP3A5;HSD17B7;...
Fatty acid degradation 1.66 2.58e-2 40/43 (93.02%) ACSL1;CPT1A;ALDH2;...
Collecting duct acid secretion 1.64 3.31e-2 22/27 (81.48%) ATP6V1C1;ATP6V1B1;ATP6V0A4;...
Cysteine and methionine metabolism 1.62 4.10e-2 43/50 (86%) TST;ADI1;CTH;...
Histidine metabolism 1.61 4.09e-2 16/22 (72.73%) AOC1;HNMT;ALDH2;...
beta-Alanine metabolism 1.60 4.20e-2 25/30 (83.33%) ABAT;ALDH2;ALDH6A1;...
Fatty acid elongation 1.60 4.08e-2 19/27 (70.37%) ACAA2;HADHB;HSD17B12;...
Peroxisome 1.59 4.29e-2 72/82 (87.8%) HSD17B4;PHYH;ACSL1;...
Ubiquitin mediated proteolysis 1.58 4.24e-2 87/140 (62.14%) DDB2;MDM2;STUB1;...
Leukocyte transendothelial migration -1.67 4.46e-2 90/114 (78.95%) RHOH;RAP1A;PIK3CD;...
Renin secretion -1.68 3.78e-2 61/69 (88.41%) KCNJ2;ADORA1;PPP3R1;...
Base excision repair -1.69 3.71e-2 29/33 (87.88%) POLD3;PARP3;POLD2;...
Mismatch repair -1.74 2.79e-2 22/23 (95.65%) POLD3;POLD2;PCNA;...
Cell cycle -1.75 2.64e-2 110/124 (88.71%) CCNE2;SKP1;E2F1;...
Nucleotide excision repair -1.76 2.77e-2 40/47 (85.11%) GTF2H4;POLD3;ERCC8;...
Antigen processing and presentation -1.77 2.80e-2 60/78 (76.92%) HSPA8;HLA-DPA1;HSPA5;...
Th1 and Th2 cell differentiation -1.78 2.61e-2 80/92 (86.96%) MAPK1;IFNGR2;IFNGR1;...
Gap junction -1.78 2.77e-2 72/88 (81.82%) NRAS;GNAS;PDGFRA;...
Pertussis -1.86 1.04e-2 64/76 (84.21%) TRAF6;MYD88;TNF;...
Spliceosome -1.87 1.02e-2 101/150 (67.33%) SRSF10;DDX46;HSPA8;...
TNF signaling pathway -1.90 9.88e-3 103/112 (91.96%) NOD2;AKT3;IFNB1;...
Chemokine signaling pathway -1.91 7.11e-3 163/192 (84.9%) GSK3A;CXCR3;PIK3R1;...
Proteasome -1.92 5.93e-3 44/46 (95.65%) PSME2;PSMC6;PSMD1;...
Viral protein interaction with cytokine and cytokine re... -2.04 0.00e+0 84/100 (84%) PF4V1;IL18R1;CSF1;...
IL-17 signaling pathway -2.05 0.00e+0 84/94 (89.36%) MAPK1;TRAF2;HSP90B1;...
DNA replication -2.33 0.00e+0 34/36 (94.44%) POLD3;RNASEH1;DNA2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.08uM - 10uM 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.08uM - 10uM 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.08uM - 10uM 6H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 3.33uM 24H