Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCLWDJ)

Drug Name
Lumacaftor Drug Info
Synonyms VRT-325; VRT-422; VRT-532; VX-809
Cross-matching ID
PubChem CID
16678941
ChEBI ID
CHEMBL2103870
CAS Number
CAS 936727-05-8
TTD Drug ID
D0X0CB
VARIDT Drug ID
DR01156

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.41 0.00e+0 34/36 (94.44%) MCM6;PCNA;MCM5;...
Cell cycle 2.34 0.00e+0 110/124 (88.71%) MCM6;PCNA;CDC20;...
Ribosome biogenesis in eukaryotes 2.07 0.00e+0 52/108 (48.15%) NVL;CSNK2B;NOP56;...
Base excision repair 1.99 2.58e-3 29/33 (87.88%) PCNA;PARP2;SMUG1;...
Arginine biosynthesis 1.92 6.20e-3 17/22 (77.27%) GLUL;GLUD1;CPS1;...
Mismatch repair 1.88 1.21e-2 22/23 (95.65%) PCNA;MSH6;RFC4;...
Oxidative phosphorylation -1.94 1.45e-2 93/133 (69.92%) NDUFS4;COX6C;ATP5MC2;...
Vibrio cholerae infection -1.97 9.68e-3 44/50 (88%) ATP6V0E2;ERO1A;SEC61A2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H