Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCMBHA)

Drug Name
Erlotinib Drug Info
Synonyms
Erlotinin; Tarceva; Erlotinib Base; OSI 744; R 1415; CP 358,774; CP-358774; Erlotinib(Tarceva); Tarceva (TN); CP-358,774; Erlotinib, OS-774; N-(3-ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-Quinazolinamine; [6,7-BIS(2-METHOXY-ETHOXY)QUINAZOLINE-4-YL]-(3-ETHYNYLPHENYL)AMINE; [6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine; 4-[(3-Ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline; 4-[(3-ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
176870
ChEBI ID
CHEMBL114785
CAS Number
CAS 183321-74-6
TTD Drug ID
D07POC
VARIDT Drug ID
DR00558
INTEDE Drug ID
DR0603
ACDINA Drug ID
D00239

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cysteine and methionine metabolism 2.38 0.00e+0 43/50 (86%) PHGDH;PSAT1;CBS;...
Ribosome 2.38 0.00e+0 113/158 (71.52%) RPS4Y1;MRPS16;RSL24D1;...
Glycine, serine and threonine metabolism 2.31 0.00e+0 31/40 (77.5%) PHGDH;PSAT1;CBS;...
Alanine, aspartate and glutamate metabolism 2.19 0.00e+0 27/37 (72.97%) ASNS;ASS1;GOT1;...
One carbon pool by folate 2.18 0.00e+0 15/20 (75%) SHMT2;MTHFD2;MTHFD1;...
Pantothenate and CoA biosynthesis 2.00 1.28e-3 14/21 (66.67%) ALDH2;BCAT1;DPYS;...
Fanconi anemia pathway 1.94 1.10e-3 36/54 (66.67%) USP1;RMI1;REV3L;...
beta-Alanine metabolism 1.86 7.67e-3 25/30 (83.33%) ALDH6A1;ALDH3A1;ALDH2;...
DNA replication 1.76 2.13e-2 34/36 (94.44%) PCNA;PRIM1;RNASEH2A;...
Arginine biosynthesis 1.75 2.38e-2 17/22 (77.27%) ASS1;GOT1
Metabolism of xenobiotics by cytochrome P450 1.74 2.37e-2 49/77 (63.64%) AKR1C1;GSTA1;ALDH3A1;...
Fatty acid degradation 1.70 3.32e-2 40/43 (93.02%) ECI1;ALDH2;EHHADH;...
Histidine metabolism 1.70 3.13e-2 16/22 (72.73%) ALDH3A1;ALDH2;ASPA;...
Lysine degradation 1.70 2.96e-2 51/63 (80.95%) MECOM;ALDH2;EHHADH;...
Folate biosynthesis 1.65 4.40e-2 23/26 (88.46%) AKR1C3;PAH;MOCOS;...
Homologous recombination 1.64 4.60e-2 35/41 (85.37%) RBBP8;RPA3;POLD2;...
Steroid hormone biosynthesis 1.63 4.78e-2 43/61 (70.49%) AKR1C2;AKR1C3;AKR1C1;...
Tryptophan metabolism 1.61 4.99e-2 35/42 (83.33%) ALDH2;IDO1;EHHADH;...
Colorectal cancer -1.66 2.59e-2 84/86 (97.67%) AKT1;PIK3CB;APC2;...
Regulation of lipolysis in adipocytes -1.68 2.45e-2 52/55 (94.55%) ADRB2;ADORA1;NPY;...
Parathyroid hormone synthesis, secretion and action -1.69 2.32e-2 98/106 (92.45%) PLCB3;MMP14;ARHGEF1;...
Kaposi sarcoma-associated herpesvirus infection -1.70 2.19e-2 172/193 (89.12%) STAT3;MAP2K1;NRAS;...
Pathogenic Escherichia coli infection -1.71 2.22e-2 152/197 (77.16%) RAC1;ARHGEF1;MYH10;...
Viral myocarditis -1.72 1.93e-2 53/60 (88.33%) ITGAL;HLA-A;SGCB;...
Cytokine-cytokine receptor interaction -1.73 1.96e-2 246/295 (83.39%) CCL8;IFNB1;IL18R1;...
Terpenoid backbone biosynthesis -1.76 1.41e-2 18/22 (81.82%) FDPS;HMGCR;MVD;...
Malaria -1.76 1.42e-2 44/50 (88%) COMP;CCL2;IL10;...
Endocytosis -1.79 1.26e-2 198/252 (78.57%) EHD4;RAB5A;HLA-A;...
Toxoplasmosis -1.81 1.08e-2 103/112 (91.96%) MAP3K7;STAT3;MYD88;...
Tight junction -1.81 1.14e-2 130/169 (76.92%) MYL6;PPP2R2D;SYNPO;...
Biosynthesis of unsaturated fatty acids -1.85 1.07e-2 21/27 (77.78%) HSD17B12;SCD5;HACD1;...
Leukocyte transendothelial migration -1.86 9.21e-3 90/114 (78.95%) PIK3R3;ITGAL;JAM2;...
Focal adhesion -1.87 9.03e-3 180/201 (89.55%) PIK3R1;BAD;COL2A1;...
Vibrio cholerae infection -1.92 4.01e-3 44/50 (88%) ATP6V1G1;PDIA4;KDELR2;...
Amoebiasis -1.92 4.30e-3 99/102 (97.06%) TGFB2;CD1B;RELA;...
Rheumatoid arthritis -1.97 1.85e-3 78/93 (83.87%) ATP6V1A;ATP6V0D1;CTSK;...
Proteoglycans in cancer -1.97 2.01e-3 172/205 (83.9%) GPC3;ITGA5;FZD8;...
Mucin type O-glycan biosynthesis -1.98 2.19e-3 20/36 (55.56%) C1GALT1;ST3GAL2;B4GALT5;...
Hematopoietic cell lineage -1.98 2.41e-3 90/99 (90.91%) ITGA5;CD1B;IL5;...
Small cell lung cancer -2.02 1.34e-3 90/92 (97.83%) CDKN2B;LAMC1;RB1;...
Bacterial invasion of epithelial cells -2.02 1.51e-3 59/77 (76.62%) ITGB1;PIK3R1;SHC3;...
Glycosaminoglycan biosynthesis -2.05 1.72e-3 40/58 (68.97%) CHSY1;NDST1;EXTL2;...
Lysosome -2.07 0.00e+0 115/128 (89.84%) CD63;CTNS;HYAL3;...
IL-17 signaling pathway -2.07 0.00e+0 84/94 (89.36%) FADD;IL13;TRAF4;...
ECM-receptor interaction -2.07 0.00e+0 80/88 (90.91%) ITGB8;ITGA5;CD47;...
Phagosome -2.15 0.00e+0 118/152 (77.63%) RAB5A;HLA-A;MSR1;...
Epithelial cell signaling in Helicobacter pylori infect... -2.19 0.00e+0 62/70 (88.57%) ADAM17;RAC1;GIT1;...
Steroid biosynthesis -2.24 0.00e+0 19/20 (95%) CYP24A1;LIPA;TM7SF2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 0.12uM - 10uM 24H
TC-32 CVCL_7141 Homo sapiens 0.12uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 0.12uM - 1.11uM 24H
YH-13 CVCL_1800 Homo sapiens 0.12uM - 10uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 0.12uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 20uM 3H, 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 0.12uM - 10uM 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H, XH
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.12uM - 10uM 24H
T-47D CVCL_0553 Homo sapiens 0.12uM - 10uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.12uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GP2d CVCL_1234 Homo sapiens 0.12uM - 10uM 24H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H, XH
NCI-H508 CVCL_1561 Homo sapiens 0.66uM - 10uM XH
SNU-407 CVCL_5004 Homo sapiens 0.12uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.12uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.12uM - 10uM 24H
HEC-151 CVCL_2927 Homo sapiens 0.12uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.12uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.12uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 0.12uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 0.12uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 0.12uM - 10uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.12uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H, XH
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 1.11uM - 8uM 72H
JHH-5 CVCL_1320 Homo sapiens 0.12uM - 10uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.12uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 20uM 6H, 24H, 48H, XH
NCI-H1975 CVCL_1511 Homo sapiens 0.66uM - 10uM XH
NCI-H1437 CVCL_1472 Homo sapiens 0.12uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 0.12uM - 10uM 24H
NCI-H1975 CVCL_1511 Homo sapiens 0.66uM - 10uM XH
NCI-H838 CVCL_1594 Homo sapiens 0.12uM - 10uM 24H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 0.66uM - 10uM XH
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 0.12uM - 10uM 24H
HCC1588 CVCL_1263 Homo sapiens 0.12uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 0.12uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 0.66uM - 10uM XH
NCI-H2110 CVCL_1529 Homo sapiens 0.12uM - 10uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.12uM - 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H841 CVCL_1595 Homo sapiens 0.12uM - 10uM 24H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 24H
SU-DHL-4 CVCL_0539 Homo sapiens 0.66uM - 10uM XH
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Mantle cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MINO CVCL_4965 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 0.12uM - 10uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 0.12uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVK18 CVCL_1629 Homo sapiens 0.12uM - 10uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.12uM - 10uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.12uM - 10uM 24H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 0.12uM - 10uM 24H
OC 316 CVCL_1615 Homo sapiens 0.12uM - 10uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 0.12uM - 10uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.12uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.12uM - 10uM 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.12uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H, XH
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H, XH
IGR-37 CVCL_1303 Homo sapiens 0.12uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 0.12uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 0.12uM - 10uM 24H
SK-MEL-3 CVCL_0525 Homo sapiens 0.12uM - 10uM 24H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.12uM - 10uM 24H
MKN45 CVCL_0434 Homo sapiens 0.12uM - 10uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.12uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 0.12uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 0.12uM - 10uM 24H