Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCMETN)

Drug Name	MLN9708 Drug Info
Cross-matching ID	PubChem CID 49867936 ChEBI ID CHEMBL1813256 CAS Number CAS 1201902-80-8 TTD Drug ID D01MML INTEDE Drug ID DR0901

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Proteasome	2.77	0.00e+0	44/46 (95.65%)	PSMD11;PSMD2;PSMB2;...
Parkinson disease	2.29	0.00e+0	176/249 (70.68%)	UCHL1;PSMD11;TUBB2A;...
Epithelial cell signaling in Helicobacter pylori infect...	2.13	0.00e+0	62/70 (88.57%)	ATP6V1A;ATP6V0E1;PTPRZ1;...
Protein processing in endoplasmic reticulum	2.13	0.00e+0	127/171 (74.27%)	HSPA1A;CRYAB;NSFL1C;...
Spinocerebellar ataxia	2.11	0.00e+0	128/143 (89.51%)	PSMD11;PSMD2;PSMB2;...
Collecting duct acid secretion	2.10	0.00e+0	22/27 (81.48%)	ATP6V1A;ATP6V0E1;ATP6V1D;...
Amyotrophic lateral sclerosis	2.02	0.00e+0	267/364 (73.35%)	SQSTM1;PSMD11;TUBB2A;...
Huntington disease	2.00	0.00e+0	233/306 (76.14%)	PSMD11;TUBB2A;PSMD2;...
Lysosome	1.96	1.02e-3	115/128 (89.84%)	MAN2B1;NPC1;CLTB;...
Salmonella infection	1.95	9.22e-4	198/249 (79.52%)	TUBB2A;TXN;MYC;...
Protein export	1.93	1.68e-3	17/23 (73.91%)	SRP54;SEC61A2;SRPRB;...
Pathways of neurodegeneration	1.89	3.07e-3	354/475 (74.53%)	UCHL1;SQSTM1;PSMD11;...
Prion disease	1.89	2.84e-3	209/273 (76.56%)	HSPA1A;PSMD11;TUBB2A;...
Vibrio cholerae infection	1.86	3.95e-3	44/50 (88%)	ATP6V1A;ATP6V0E1;ATP6V1D;...
Alzheimer disease	1.81	7.38e-3	279/369 (75.61%)	IDE;PSMD11;TUBB2A;...
Sphingolipid metabolism	1.73	1.73e-2	32/49 (65.31%)	GLA;SPTLC2;PSAP;...
TNF signaling pathway	1.72	1.84e-2	103/112 (91.96%)	JAG1;CXCL2;TNFRSF1A;...
Mitophagy	1.67	2.87e-2	56/68 (82.35%)	SQSTM1;GABARAPL1;CSNK2A1;...
Synaptic vesicle cycle	1.67	2.91e-2	63/78 (80.77%)	DNM1;ATP6V1A;CLTB;...
Legionellosis	1.66	3.23e-2	51/57 (89.47%)	HSPA1A;SAR1B;VCP;...
Phagosome	1.64	3.78e-2	118/152 (77.63%)	TUBB2A;ATP6V1A;ATP6V0E1;...
Autophagy	1.62	4.23e-2	113/169 (66.86%)	SQSTM1;GABARAPL1;CTSD;...
Vasopressin-regulated water reabsorption	1.60	4.89e-2	40/44 (90.91%)	DCTN6;RAB5A;DYNC1H1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H

MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 3.33uM	24H

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H