Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCMJRA)

• Drug Name: EGF816 Drug Info
• Cross-matching ID:
  PubChem CID: 72703790
  ChEBI ID: CHEMBL3787344
  CAS Number: CAS 1508250-71-2
  TTD Drug ID: D0K7FY

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.68	0.00e+0	19/20 (95%)	DHCR24;MSMO1;SQLE;...
Biosynthesis of unsaturated fatty acids	2.19	0.00e+0	21/27 (77.78%)	SCD;ELOVL6;FADS1;...
Lysosome	2.16	0.00e+0	115/128 (89.84%)	NEU1;TPP1;MCOLN1;...
Terpenoid backbone biosynthesis	2.12	0.00e+0	18/22 (81.82%)	HMGCS1;ACAT2;FDPS;...
Synthesis and degradation of ketone bodies	1.97	5.11e-3	9/10 (90%)	HMGCS1;ACAT2
PPAR signaling pathway	1.89	8.52e-3	66/74 (89.19%)	SCD;HMGCS1;ACSL1;...
Collecting duct acid secretion	1.85	1.34e-2	22/27 (81.48%)	ATP6V0D1;ATP6V1C1;ATP6V1B2;...
Fatty acid elongation	1.78	2.87e-2	19/27 (70.37%)	ELOVL6;ELOVL4;ELOVL5;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	2.5uM - 20uM	24H	Hide ▲

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	2.5uM - 20uM	24H	Hide ▲