Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCOLUP)

• Drug Name: Levallorphan Drug Info
• Synonyms: Levallofano; Levallorphane; Levallorphanum; Levalorfano; Naloxiphan; Levallofano [DCIT]; Levallorphan [INN:BAN]; Levallorphane [INN-French]; Levallorphanum [INN-Latin]; Levalorfano [INN-Spanish]; Lorfan (TN); Ro-1-7700; N-Allyl-3-hydroxymorphinan; L-N-Allyl-3-hydroxymorphinan; Levo-3-hydroxy-N-allyl morphinan; (-)-3-Hydroxy-N-allylmorphinan; 17-Allylmorphinan-3-ol; 17-prop-2-en-1-ylmorphinan-3-ol
• Therapeutic Class: Antinarcotic Agents
• Cross-matching ID:
  PubChem CID: 5359371
  ChEBI ID: CHEMBL1254682
  CAS Number: CAS 152-02-3
  TTD Drug ID: D04QWE

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.14	0.00e+0	34/36 (94.44%)	PRIM2;POLE3;FEN1;...
Retinol metabolism	1.89	5.58e-3	41/68 (60.29%)	AOX1;DHRS3;UGT2A3;...
One carbon pool by folate	1.84	1.49e-2	15/20 (75%)	MTR;DHFR;AMT;...
Asthma	1.76	4.18e-2	25/31 (80.65%)	CD40;HLA-DQA1;FCER1A;...
Tyrosine metabolism	1.73	4.46e-2	30/36 (83.33%)	AOX1;DCT;MAOB;...
Staphylococcus aureus infection	-1.76	4.51e-2	72/95 (75.79%)	ITGB2;KRT10;SELPLG;...
Oxidative phosphorylation	-1.87	2.25e-2	93/133 (69.92%)	NDUFB8;COX11;NDUFA2;...
Complement and coagulation cascades	-1.92	3.61e-2	76/85 (89.41%)	C4BPB;CFI;C8B;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲