Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCOQKH)

Drug Name
C646 Drug Info
Synonyms
328968-36-1; CHEMBL1797936; 4-[(4Z)-4-[[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid; C24H19N3O6; 4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid; C 646; AC1LPE4V; GTPL7004; SCHEMBL12092858; QCR-235; DTXSID30361651; MolPort-002-171-380; CHEBI:132974; ZINC8780879; s7152; 2295AH; AKOS000113052; SB19338; ST020490; C646, > J-018925; BRD-K73383190-001-03-1
Cross-matching ID
PubChem CID
1285940
ChEBI ID
CHEMBL3734823
CAS Number
CAS 328968-36-1
TTD Drug ID
D0YL8Z

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Endometrial cancer 1.92 1.11e-2 56/58 (96.55%) CDKN1A;ERBB2;TP53;...
Peroxisome 1.89 1.11e-2 72/82 (87.8%) PEX11A;ECH1;HMGCL;...
Basal cell carcinoma 1.81 4.08e-2 41/63 (65.08%) CDKN1A;TP53;BAX;...
Mannose type O-glycan biosynthesis 1.80 3.06e-2 14/23 (60.87%) LARGE1;POMGNT1;B4GAT1;...
Chronic myeloid leukemia 1.76 4.22e-2 72/76 (94.74%) CDKN1A;TP53;BAX;...
Thyroid cancer 1.74 4.08e-2 36/37 (97.3%) CDKN1A;TP53;BAX;...
Shigellosis 1.72 4.92e-2 180/246 (73.17%) TP53;MYL9;BAX;...
Pyrimidine metabolism -1.69 3.86e-2 40/56 (71.43%) NUDT2;UCK2;CDA;...
Cortisol synthesis and secretion -1.70 3.65e-2 58/65 (89.23%) PBX1;CYP21A2;CACNA1H;...
Protein processing in endoplasmic reticulum -1.70 3.90e-2 127/171 (74.27%) HSPH1;ERO1A;SAR1A;...
One carbon pool by folate -1.75 1.64e-2 15/20 (75%) MTHFD1;SHMT2;DHFR;...
Non-homologous end-joining -1.80 8.11e-3 11/13 (84.62%) XRCC5;PRKDC;DCLRE1C;...
Fanconi anemia pathway -2.01 1.14e-3 36/54 (66.67%) ATR;FANCE;FAAP24;...
Oocyte meiosis -2.11 1.30e-3 90/129 (69.77%) CDC27;PPP2R5E;PGR;...
Base excision repair -2.11 1.52e-3 29/33 (87.88%) NTHL1;LIG1;HMGB1;...
Progesterone-mediated oocyte maturation -2.13 1.83e-3 75/100 (75%) ANAPC10;MAP2K1;ADCY7;...
Homologous recombination -2.19 0.00e+0 35/41 (85.37%) RPA1;BRIP1;BRCA2;...
Mismatch repair -2.29 0.00e+0 22/23 (95.65%) RFC5;LIG1;RPA1;...
Cell cycle -2.31 0.00e+0 110/124 (88.71%) ANAPC10;SMC3;WEE1;...
DNA replication -2.53 0.00e+0 34/36 (94.44%) POLA1;RFC5;LIG1;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 20uM 6H
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NPC-B13 CVCL_D3FG Homo sapiens 10uM XH
Bone marrow
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NPC-BM00 CVCL_B3QC Homo sapiens 10uM XH
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 25uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 20uM 6H
HT-29 CVCL_0320 Homo sapiens 0.04uM - 20uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 20uM 6H
MDST8 CVCL_1400 Homo sapiens 20uM 6H
NCI-H508 CVCL_1561 Homo sapiens 20uM 6H
SNU-1040 CVCL_5001 Homo sapiens 20uM 6H
SNU-C4 CVCL_5008 Homo sapiens 20uM 6H
SNU-C5 CVCL_5009 Homo sapiens 20uM 6H
SW480 CVCL_0546 Homo sapiens 20uM 6H
SW620 CVCL_0547 Homo sapiens 20uM 6H
SW948 CVCL_0550 Homo sapiens 20uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 20uM 6H
HT115 CVCL_1294 Homo sapiens 20uM 6H
RKO CVCL_0504 Homo sapiens 20uM 6H
Dental pulp
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
iPS-DP31 3f-2 CVCL_DP83 Homo sapiens 10uM XH
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 20uM 6H
SNG-M CVCL_1707 Homo sapiens 20uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 20uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 20uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 20uM 6H, 24H
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NPC2-hTERT CVCL_B6EI Homo sapiens 10uM XH
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 25uM 6H, 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
DV-90 CVCL_1184 Homo sapiens 20uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 20uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 20uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 20uM 6H
T3M-10 CVCL_1729 Homo sapiens 20uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 20uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 20uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 20uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 20uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 20uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 20uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 20uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 20uM 6H
OV7 CVCL_1623 Homo sapiens 20uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 20uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 20uM 6H
RMUG-S CVCL_1666 Homo sapiens 20uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 20uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 25uM 6H, 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 20uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 20uM 6H
PL-21 CVCL_2161 Homo sapiens 20uM 6H
SKM-1 CVCL_0010 Homo sapiens 20uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Pharynx, nasopharynx
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NPC-TY861 CVCL_A5WW Homo sapiens 10uM XH
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 20uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 25uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 20uM 6H, 24H
Skin
Alzheimer's disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ND347327 CVCL_EZ03 Homo sapiens 10uM XH
Gaucher disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GD-iPS3 CVCL_C949 Homo sapiens 10uM XH
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 25uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
SK-MEL-1 CVCL_0523 Homo sapiens 20uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 20uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 20uM 6H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H
Unclear
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NPC-204 CVCL_A5WV Homo sapiens 10uM XH