Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCP1G9)

Drug Name
chelerythrine Drug Info
Synonyms broussonpapyrine; cheleritrine; chelerythrine hydroxide; toddalin
Cross-matching ID
PubChem CID
2703
ChEBI ID
CHEMBL78373
CAS Number
CAS 34316-15-9
TTD Drug ID
D0T9ZL
VARIDT Drug ID
DR00988

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycine, serine and threonine metabolism 2.06 1.23e-2 31/40 (77.5%) CBS;PHGDH;PSAT1;...
Ferroptosis 2.03 1.23e-2 36/41 (87.8%) HMOX1;SLC39A14;SLC3A2;...
Staphylococcus aureus infection 2.02 8.17e-3 72/95 (75.79%) KRT19;KRT15;HLA-DQA1;...
Central carbon metabolism in cancer 1.99 9.19e-3 67/70 (95.71%) SLC7A5;MET;PDGFRA;...
Cysteine and methionine metabolism 1.98 7.35e-3 43/50 (86%) CBS;PHGDH;PSAT1;...
Antigen processing and presentation 1.93 8.17e-3 60/78 (76.92%) HLA-DQA1;HLA-DPA1;CREB1;...
Glutathione metabolism 1.89 1.05e-2 43/57 (75.44%) CHAC1;GSTA1;GCLC;...
One carbon pool by folate 1.87 9.19e-3 15/20 (75%) MTHFD2;SHMT2;MTHFD1;...
Graft-versus-host disease 1.85 1.63e-2 32/42 (76.19%) HLA-DQA1;HLA-DPA1;HLA-DQB1;...
Galactose metabolism 1.80 2.33e-2 26/31 (83.87%) AKR1B10;PFKM;PFKP;...
Fructose and mannose metabolism 1.77 2.56e-2 30/33 (90.91%) SORD;ALDOB;AKR1B10;...
Systemic lupus erythematosus 1.76 2.55e-2 45/135 (33.33%) HLA-DQA1;HLA-DPA1;CD40;...
Allograft rejection 1.72 3.96e-2 32/38 (84.21%) HLA-DQA1;HLA-DPA1;CD40;...
Arginine and proline metabolism 1.71 3.94e-2 39/50 (78%) ALDH2;ARG2;PYCR1;...
African trypanosomiasis 1.71 3.76e-2 32/37 (86.49%) VCAM1;APOL1;IDO1;...
Protein digestion and absorption 1.71 3.52e-2 78/103 (75.73%) COL1A2;SLC3A1;SLC3A2;...
DNA replication 1.69 3.89e-2 34/36 (94.44%) FEN1;MCM5;RFC4;...
Synaptic vesicle cycle -1.78 2.29e-2 63/78 (80.77%) SLC6A11;STX3;SLC6A2;...
Parkinson disease -1.85 8.67e-3 176/249 (70.68%) ATP5PF;HTRA2;PSMB4;...
Thermogenesis -1.88 7.22e-3 173/232 (74.57%) ATP5PF;ATF2;SDHB;...
Vibrio cholerae infection -1.89 7.22e-3 44/50 (88%) ATP6AP1;SEC61A2;ATP6V0B;...
Hedgehog signaling pathway -1.90 1.08e-2 43/56 (76.79%) SPOP;HHAT;SHH;...
Oxidative phosphorylation -2.84 0.00e+0 93/133 (69.92%) ATP5PF;SDHB;ATP5MG;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 3.33uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 3.33uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 3.33uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 3.33uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 3.33uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 3.33uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 3.33uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 3.33uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 3.33uM 24H