Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCQ6C4)

Drug Name
Chlortetracycline Drug Info
Synonyms Aureomycin
Cross-matching ID
PubChem CID
54675777
ChEBI ID
CHEMBL27644
CAS Number
CAS 57-62-5
TTD Drug ID
D0R6RC

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Valine, leucine and isoleucine degradation 1.97 1.84e-2 42/48 (87.5%) ALDH2;MCCC1;HIBCH;...
Tyrosine metabolism 1.88 1.84e-2 30/36 (83.33%) TYRP1;ADH1C;AOC3;...
Fatty acid degradation 1.87 1.84e-2 40/43 (93.02%) ECI2;ALDH2;ADH1C;...
Arachidonic acid metabolism 1.84 2.30e-2 48/61 (78.69%) GPX2;PTGIS;ALOX5;...
beta-Alanine metabolism 1.84 1.84e-2 25/30 (83.33%) ALDH2;AOC3;HIBCH;...
Phenylalanine metabolism 1.82 1.84e-2 14/17 (82.35%) AOC3;ALDH3A1;PAH;...
Arginine and proline metabolism 1.77 2.76e-2 39/50 (78%) CKB;ALDH2;ARG1;...
Sulfur metabolism 1.77 2.41e-2 9/10 (90%) SQOR;PAPSS2;SUOX;...
Drug metabolism 1.75 2.76e-2 78/151 (51.66%) FMO1;GSTO1;ADH1C;...
Pantothenate and CoA biosynthesis 1.73 3.04e-2 14/21 (66.67%) ENPP1;ALDH2;PPCDC;...
Staphylococcus aureus infection -1.82 1.76e-2 72/95 (75.79%) ITGB2;C1R;KRT16;...
Mineral absorption -1.90 2.74e-3 48/60 (80%) CLCN2;SLC26A6;SLC34A2;...
Nicotine addiction -1.91 3.66e-3 32/40 (80%) SLC17A6;GABRA5;GRIA4;...
Primary immunodeficiency -1.92 0.00e+0 33/38 (86.84%) RAG1;RFX5;CIITA;...
Morphine addiction -2.14 0.00e+0 80/91 (87.91%) CACNA1A;GRK5;PDE10A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H