Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCQ7UN)

• Drug Name: Fentiazac Drug Info
• Synonyms: FENTIAZAC; Donorest; Flogene; Norvedan; 18046-21-4; BR 700; UNII-0YHF6E6NLS; Fentiazacum [INN-Latin]; Fentiazaco [INN-Spanish]; 2-(4-(4-chlorophenyl)-2-phenylthiazol-5-yl)acetic acid; EINECS 241-958-1; CH 800; 0YHF6E6NLS; NSC 282191; C17H12ClNO2S; 4-(p-Chlorophenyl)-2-phenyl-5-thiazoleacetic acid; BRN 1083610; 5-Thiazoleacetic acid, 4-(p-chlorophenyl)-2-phenyl-; 5-Thiazoleacetic acid, 4-(4-chlorophenyl)-2-phenyl-; MLS003115545; WY 21,894; CHEMBL589092; 4-(4-Chlorophenyl)-2-phenyl-5-thiazoleacetic acid; NCGC00182976-01
• Cross-matching ID:
  PubChem CID: 28871
  ChEBI ID: CHEMBL589092
  CAS Number: CAS 18046-21-4
  TTD Drug ID: D0YB1G

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Mineral absorption	2.51	0.00e+0	48/60 (80%)	MT1E;MT1F;MT1X;...
Thiamine metabolism	1.90	3.63e-2	12/15 (80%)	AK4;AK1;AK2;...
RNA degradation	1.89	2.42e-2	53/79 (67.09%)	EXOSC4;BTG3;CNOT7;...
Nitrogen metabolism	1.89	1.82e-2	16/17 (94.12%)	GLUL;CA12;CA2;...
Sphingolipid metabolism	-1.76	4.46e-2	32/49 (65.31%)	CERS2;ASAH1;GAL3ST1;...
Allograft rejection	-1.85	3.34e-2	32/38 (84.21%)	HLA-DQA1;HLA-DPA1;IFNG;...
Graft-versus-host disease	-1.87	4.46e-2	32/42 (76.19%)	FASLG;KIR2DL1;KIR2DL3;...
Type I diabetes mellitus	-2.04	1.11e-2	38/43 (88.37%)	ICA1;PTPRN2;GAD1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.04uM - 10uM	6H, 24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	10uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼