Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCT2YF)

Drug Name
Emetine Drug Info
Synonyms
Emetine hydrochloride; EMETINE; 14198-59-5; MLS000028478; SMR000058444; NSC-33669; NSC33669; Emetine monohydrochloride; Opera_ID_1460; Cephaeline methyl ether HCl; AC1O7FP4; SCHEMBL636599; CHEMBL513000; DTXSID80424947; MolPort-004-964-890; Cephaeline methyl ether hydrochloride; NSC752340; AKOS024374935; NSC-752340; ST51014995; Emetan,7',10,11-tetramethoxy-, dihydrochloride; Q-100155; 10-[((1R)-6,7-dimethoxy(1,2,3,4-tetrahydroisoquinolyl))methyl](10S,11aS,9R)-9- ethyl-2,3-dimethoxy-5,6,7,11a-tetrahydropiperidino[2,1-a]isoquinolin
Cross-matching ID
PubChem CID
10219
ChEBI ID
CHEMBL50588
CAS Number
CAS 483-18-1
TTD Drug ID
D07DJQ
VARIDT Drug ID
DR00554
INTEDE Drug ID
DR0571

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
RIG-I-like receptor signaling pathway 1.98 1.55e-2 64/70 (91.43%) NFKBIA;NFKB1;IKBKE;...
Ribosome biogenesis in eukaryotes 1.93 2.33e-2 52/108 (48.15%) RPP38;GTPBP4;NVL;...
Cytosolic DNA-sensing pathway 1.91 1.81e-2 52/63 (82.54%) NFKBIA;POLR3C;NFKB1;...
Cell cycle 1.89 1.55e-2 110/124 (88.71%) GADD45B;GADD45A;MYC;...
Circadian rhythm 1.87 1.40e-2 26/31 (83.87%) BHLHE40;PER1;PER2;...
Ubiquitin mediated proteolysis 1.85 1.43e-2 87/140 (62.14%) MID1;BIRC3;CDC20;...
NF-kappa B signaling pathway 1.78 1.78e-2 90/104 (86.54%) RELB;GADD45B;NFKBIA;...
TNF signaling pathway 1.77 1.75e-2 103/112 (91.96%) JUN;NFKBIA;NFKB1;...
C-type lectin receptor signaling pathway 1.74 2.33e-2 93/104 (89.42%) RELB;JUN;NFKBIA;...
Basal transcription factors 1.73 2.25e-2 37/45 (82.22%) MNAT1;TAF2;TAF9;...
mRNA surveillance pathway 1.71 2.33e-2 71/98 (72.45%) PCF11;CSTF3;FIP1L1;...
Protein digestion and absorption -1.66 2.42e-2 78/103 (75.73%) COL4A5;SLC15A1;COL11A1;...
Fluid shear stress and atherosclerosis -1.67 2.38e-2 123/139 (88.49%) BMPR1A;ACTB;RAC2;...
Cardiac muscle contraction -1.68 2.34e-2 64/87 (73.56%) CACNB4;CACNB1;COX7C;...
Other types of O-glycan biosynthesis -1.68 2.25e-2 29/47 (61.7%) ST6GAL1;B4GALT2;GALNT11;...
Sphingolipid metabolism -1.69 2.21e-2 32/49 (65.31%) CERS2;KDSR;SGPL1;...
Bile secretion -1.69 2.20e-2 68/90 (75.56%) ATP1A2;ADCY2;ADCY9;...
N-Glycan biosynthesis -1.73 1.46e-2 38/50 (76%) FUT8;SRD5A3;ALG12;...
Glycosaminoglycan biosynthesis -1.73 1.42e-2 40/58 (68.97%) HS2ST1;CHPF;HS3ST3A1;...
Fatty acid elongation -1.74 1.38e-2 19/27 (70.37%) ELOVL5;HADH;HACD2;...
Glycosaminoglycan degradation -1.75 1.23e-2 19/19 (100%) HYAL1;ARSB;HPSE;...
Biosynthesis of unsaturated fatty acids -1.76 1.23e-2 21/27 (77.78%) ELOVL5;HACD2;HSD17B12;...
Other glycan degradation -1.76 1.23e-2 13/18 (72.22%) FUCA1;ENGASE;NEU1;...
Amino sugar and nucleotide sugar metabolism -1.77 1.11e-2 38/48 (79.17%) PGM3;UGDH;UGP2;...
Glycine, serine and threonine metabolism -1.77 1.03e-2 31/40 (77.5%) AMT;SDS;SHMT2;...
Mineral absorption -1.79 8.78e-3 48/60 (80%) ATP1A2;ATP1A1;TF;...
Glycosphingolipid biosynthesis -1.80 7.02e-3 37/57 (64.91%) FUT3;FUT6;B3GALT2;...
Phagosome -1.82 5.85e-3 118/152 (77.63%) CLEC7A;LAMP2;SEC61B;...
Arginine biosynthesis -1.84 4.50e-3 17/22 (77.27%) GLUD1;GLUL;ARG2;...
Starch and sucrose metabolism -1.87 3.90e-3 25/36 (69.44%) SI;GYS1;GYG2;...
Mucin type O-glycan biosynthesis -1.89 4.25e-3 20/36 (55.56%) ST6GALNAC2;ST6GALNAC4;GALNT11;...
Cysteine and methionine metabolism -1.92 3.51e-3 43/50 (86%) MPST;ADI1;CTH;...
Various types of N-glycan biosynthesis -1.94 1.30e-3 26/39 (66.67%) MGAT4A;MGAT4B;B4GALT2;...
Glycolysis / Gluconeogenesis -1.94 1.46e-3 56/67 (83.58%) MINPP1;ALDH1B1;G6PC3;...
Glutathione metabolism -1.96 0.00e+0 43/57 (75.44%) GPX2;OPLAH;GSTM3;...
Alanine, aspartate and glutamate metabolism -1.97 0.00e+0 27/37 (72.97%) GLUD1;GLUL;GFPT1;...
Steroid biosynthesis -2.06 0.00e+0 19/20 (95%) TM7SF2;LBR;LSS;...
Ferroptosis -2.07 0.00e+0 36/41 (87.8%) PRNP;VDAC2;LPCAT3;...
Antigen processing and presentation -2.24 0.00e+0 60/78 (76.92%) HLA-DPB1;HLA-E;HLA-B;...
Lysosome -2.41 0.00e+0 115/128 (89.84%) GALNS;CLN3;ATP6V0A4;...
Protein processing in endoplasmic reticulum -2.42 0.00e+0 127/171 (74.27%) BAX;LMAN1;DAD1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 0.66uM 6H
SK-ES-1 CVCL_0627 Homo sapiens 0.12uM - 10uM 24H
TC-32 CVCL_7141 Homo sapiens 0.12uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 0.12uM - 10uM 24H
YH-13 CVCL_1800 Homo sapiens 0.12uM - 10uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 0.12uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 10uM 6H, 24H, 48H
MDA-MB-468 CVCL_0419 Homo sapiens 0.12uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.12uM - 10uM 24H
T-47D CVCL_0553 Homo sapiens 0.12uM - 10uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.12uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 0.66uM 6H
GP2d CVCL_1234 Homo sapiens 0.12uM - 1.11uM 24H
HT-29 CVCL_0320 Homo sapiens 0.12uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 0.66uM 6H
MDST8 CVCL_1400 Homo sapiens 0.66uM 6H
NCI-H508 CVCL_1561 Homo sapiens 0.66uM 6H
SNU-1040 CVCL_5001 Homo sapiens 0.66uM 6H
SNU-407 CVCL_5004 Homo sapiens 0.12uM - 10uM 24H
SNU-C4 CVCL_5008 Homo sapiens 0.66uM 6H
SNU-C5 CVCL_5009 Homo sapiens 0.66uM 6H
SW480 CVCL_0546 Homo sapiens 0.66uM 6H
SW620 CVCL_0547 Homo sapiens 0.66uM 6H
SW948 CVCL_0550 Homo sapiens 0.66uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 0.66uM 6H
HT115 CVCL_1294 Homo sapiens 0.66uM 6H
RKO CVCL_0504 Homo sapiens 0.66uM 6H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.12uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.66uM - 1.11uM 6H, 24H
HEC-151 CVCL_2927 Homo sapiens 0.12uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.12uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.12uM - 1.11uM 24H
HEC-265 CVCL_2929 Homo sapiens 0.12uM - 10uM 24H
SNG-M CVCL_1707 Homo sapiens 0.66uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 0.66uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 0.12uM - 1.11uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.66uM - 10uM 6H, 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 0.12uM - 10uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.12uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.66uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 2.5uM - 10uM 6H, 24H
JHH-5 CVCL_1320 Homo sapiens 0.12uM - 10uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.12uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 10uM 6H, 24H, 48H
DV-90 CVCL_1184 Homo sapiens 0.66uM 6H
NCI-H1437 CVCL_1472 Homo sapiens 0.12uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 0.12uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 0.12uM 24H
SK-LU-1 CVCL_0624 Homo sapiens 0.66uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 0.66uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 0.66uM 6H
T3M-10 CVCL_1729 Homo sapiens 0.66uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 0.12uM - 10uM 24H
HCC15 CVCL_1253 Homo sapiens 0.66uM 6H
HCC1588 CVCL_1263 Homo sapiens 0.12uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 0.12uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 0.66uM 6H
HCC515 CVCL_5134 Homo sapiens 0.66uM - 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 0.66uM 6H
NCI-H2110 CVCL_1529 Homo sapiens 0.12uM - 10uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.12uM - 1.11uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 0.66uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 0.66uM 6H
NCI-H841 CVCL_1595 Homo sapiens 0.12uM - 10uM 24H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 0.66uM 6H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 0.12uM - 10uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 0.12uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 0.66uM 6H
OV7 CVCL_1623 Homo sapiens 0.66uM 6H
OVK18 CVCL_1629 Homo sapiens 0.12uM - 1.11uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.12uM - 10uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.12uM - 10uM 24H
RMG-I CVCL_1663 Homo sapiens 0.66uM 6H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 0.12uM - 10uM 24H
OC 316 CVCL_1615 Homo sapiens 0.12uM - 10uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 0.12uM - 10uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.12uM - 10uM 24H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 0.66uM 6H
RMUG-S CVCL_1666 Homo sapiens 0.66uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 0.66uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.12uM - 1.11uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.66uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 0.66uM 6H
PL-21 CVCL_2161 Homo sapiens 0.66uM 6H
SKM-1 CVCL_0010 Homo sapiens 0.66uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 0.66uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.12uM - 10uM 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.12uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.12uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.66uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.12uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 0.12uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 0.12uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 0.12uM - 10uM 24H
SK-MEL-1 CVCL_0523 Homo sapiens 0.66uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 0.66uM 6H
SK-MEL-3 CVCL_0525 Homo sapiens 0.12uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.12uM - 1.11uM 6H, 24H
MKN45 CVCL_0434 Homo sapiens 0.12uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.12uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 0.12uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 0.12uM - 10uM 24H