Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCU1WO)

Drug Name
Eperezolid Drug Info
Synonyms PNU-100592; U-100592
Cross-matching ID
PubChem CID
73214
ChEBI ID
CHEMBL47955
CAS Number
CAS 165800-04-4
TTD Drug ID
D0YE2N

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.06 1.14e-2 113/158 (71.52%) RPS4Y1;RPL26L1;RPS5;...
Spliceosome 1.88 2.29e-2 101/150 (67.33%) SRSF3;HSPA8;LSM2;...
Primary immunodeficiency -1.68 4.89e-2 33/38 (86.84%) CD8A;AICDA;CD3D;...
Porphyrin and chlorophyll metabolism -1.76 1.93e-2 23/43 (53.49%) UGT2A3;ALAS1;CP;...
Sulfur metabolism -1.88 6.12e-3 9/10 (90%) SUOX;MPST;PAPSS2;...
Drug metabolism -1.88 7.14e-3 78/151 (51.66%) CYP2B6;MAOB;TK1;...
Malaria -1.96 3.43e-3 44/50 (88%) VCAM1;GYPA;IL18;...
Metabolism of xenobiotics by cytochrome P450 -2.04 2.14e-3 49/77 (63.64%) CYP2D6;GSTM1;CYP1A1;...
Steroid hormone biosynthesis -2.14 2.86e-3 43/61 (70.49%) HSD17B2;CYP3A7;HSD3B1;...
Retinol metabolism -2.16 4.29e-3 41/68 (60.29%) ADH5;ADH6;PNPLA4;...
Complement and coagulation cascades -2.29 0.00e+0 76/85 (89.41%) SERPINF2;VWF;C8B;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H