Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCVXBE)

Drug Name
E-64D Drug Info
Synonyms
E64D; E64d; Aloxistatin; Aloxistatin [INN]; Aloxistatina; Aloxistatina [Spanish]; Aloxistatine; Aloxistatine [French]; Aloxistatinum; Aloxistatinum [Latin]; BRN 5354546; C17H30N2O5; CCRIS 1934; CHEMBL63440; E 64c ethyl ester; E 64d; EP 453; EST; EST (pharmaceutical); L5W337AOUR; Loxistatin; MLS000028372; NSC 694281; SMR000058552; UNII-L5W337AOUR
Therapeutic ClassAntiviral Agents
Cross-matching ID
PubChem CID
65663
ChEBI ID
CHEMBL63440
CAS Number
CAS 88321-09-9
TTD Drug ID
D0NY2E

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.21 0.00e+0 93/133 (69.92%) COX17;NDUFB8;NDUFB2;...
Collecting duct acid secretion 1.99 4.11e-3 22/27 (81.48%) TCIRG1;ATP6V0A4;ATP6V1A;...
IL-17 signaling pathway 1.84 2.47e-2 84/94 (89.36%) IKBKE;CXCL8;CXCL2;...
Folate biosynthesis 1.83 1.85e-2 23/26 (88.46%) AKR1B10;ALPL;PTS;...
Epithelial cell signaling in Helicobacter pylori infect... 1.79 2.63e-2 62/70 (88.57%) CXCL8;CXCL2;CXCL3;...
Mineral absorption 1.73 4.66e-2 48/60 (80%) HMOX1;MT1E;MT1F;...
Mucin type O-glycan biosynthesis -1.64 4.85e-2 20/36 (55.56%) GALNT12;B4GALT5;GALNT3;...
Longevity regulating pathway -1.65 4.75e-2 90/151 (59.6%) PIK3R3;ATF2;FOXA2;...
Arrhythmogenic right ventricular cardiomyopathy -1.65 4.94e-2 70/77 (90.91%) ACTN2;ITGB1;DSC2;...
Leukocyte transendothelial migration -1.65 4.90e-2 90/114 (78.95%) MMP2;ITGB2;TXK;...
Estrogen signaling pathway -1.66 4.33e-2 119/137 (86.86%) MAP2K1;KRT14;ITPR2;...
PPAR signaling pathway -1.69 3.54e-2 66/74 (89.19%) FABP7;PLIN1;OLR1;...
Adrenergic signaling in cardiomyocytes -1.73 1.74e-2 130/150 (86.67%) PPP1CA;ATF2;RYR2;...
Malaria -1.74 1.86e-2 44/50 (88%) MET;CCL2;TNF;...
Adipocytokine signaling pathway -1.75 1.74e-2 64/69 (92.75%) CAMKK2;LEP;ACSL5;...
Steroid biosynthesis -1.75 1.79e-2 19/20 (95%) TM7SF2;CYP51A1;DHCR24;...
Aldosterone synthesis and secretion -1.79 1.44e-2 85/98 (86.73%) ATF1;ATF2;HSD3B1;...
Endocrine and other factor-regulated calcium reabsorpti... -1.81 1.47e-2 49/53 (92.45%) ATP1B2;SLC8A1;ADCY6;...
cGMP-PKG signaling pathway -1.83 8.80e-3 145/167 (86.83%) SRF;PPP1R12A;PPP1CA;...
Protein digestion and absorption -1.85 7.07e-3 78/103 (75.73%) ATP1B2;COL11A1;COL6A3;...
AMPK signaling pathway -1.87 3.23e-3 106/120 (88.33%) IRS1;RPS6KB1;PFKL;...
Hypertrophic cardiomyopathy -1.89 3.77e-3 81/90 (90%) ITGA2B;RYR2;TPM4;...
Focal adhesion -1.92 4.53e-3 180/201 (89.55%) ITGB1;DIAPH1;PARVB;...
Cortisol synthesis and secretion -2.02 0.00e+0 58/65 (89.23%) ATF2;HSD3B1;CREB5;...
Gap junction -2.05 0.00e+0 72/88 (81.82%) MAP2K1;DRD2;CSNK1D;...
ECM-receptor interaction -2.09 0.00e+0 80/88 (90.91%) COL6A3;ITGA7;COL4A3;...
Dilated cardiomyopathy -2.20 0.00e+0 86/96 (89.58%) ITGA2B;RYR2;TPM4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H