Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCVY4U)

Drug Name
L-689560 Drug Info
Synonyms
trans-2-Carboxy-5,7-dichloro-4-(((phenylamino)carbonyl)amino)-1,2,3,4-tetrahydroquinoline; C17H15Cl2N3O3; L 689560; L-689,560; 4-trans-2-carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline; 139051-78-8; (2S,4R)-5,7-dichloro-4-(phenylcarbamoylamino)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid; 2-Quinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-4-(((phenylamino)carbonyl)amino)-, trans-(+-)-; [3H]L689560; AC1L3TN7; SCHEMBL193615; GTPL4239; GTPL4086; ZINC2567729; compound 35
Cross-matching ID
PubChem CID
121918
CAS Number
CAS 139051-78-8
TTD Drug ID
D03UNN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Pyrimidine metabolism 1.88 1.24e-2 40/56 (71.43%) NT5E;CAD;DCTPP1;...
PPAR signaling pathway -1.62 4.61e-2 66/74 (89.19%) UBC;DBI;AQP7;...
Autoimmune thyroid disease -1.63 4.81e-2 46/53 (86.79%) IL2;TPO;HLA-DMB;...
Morphine addiction -1.63 4.70e-2 80/91 (87.91%) PDE3A;GNB2;GRK5;...
Glyoxylate and dicarboxylate metabolism -1.65 4.24e-2 23/30 (76.67%) MMUT;AMT;DLD;...
Platelet activation -1.65 4.45e-2 106/124 (85.48%) RAP1B;ROCK1;ARHGEF12;...
Cortisol synthesis and secretion -1.65 4.68e-2 58/65 (89.23%) GNA11;CREB1;CYP11A1;...
Dopaminergic synapse -1.65 4.94e-2 115/132 (87.12%) GNAI1;PRKACA;PRKACG;...
Nicotine addiction -1.68 4.31e-2 32/40 (80%) GABRD;GABRA4;GABRA5;...
Alcoholism -1.69 4.40e-2 86/186 (46.24%) GNAI1;GRIN2C;PRKACA;...
Insulin secretion -1.70 4.21e-2 75/86 (87.21%) ADCY6;RYR2;PRKACA;...
Alanine, aspartate and glutamate metabolism -1.72 4.00e-2 27/37 (72.97%) GAD2;GFPT1;GLUD2;...
Nitrogen metabolism -1.73 3.98e-2 16/17 (94.12%) CA14;CA3;CA9;...
Cocaine addiction -1.76 2.27e-2 42/49 (85.71%) GNAI1;GRIN2C;PRKACA;...
SNARE interactions in vesicular transport -1.76 2.48e-2 19/33 (57.58%) STX1A;STX18;SNAP23;...
Regulation of lipolysis in adipocytes -1.78 1.72e-2 52/55 (94.55%) PNPLA2;TSHR;AQP7;...
Cysteine and methionine metabolism -1.79 1.75e-2 43/50 (86%) BHMT;MAT2B;AHCYL1;...
Mitophagy -1.83 8.97e-3 56/68 (82.35%) MAPK9;E2F1;SP1;...
Protein export -1.84 1.03e-2 17/23 (73.91%) SEC61A1;SRP9;SPCS3;...
Carbohydrate digestion and absorption -1.92 7.18e-3 37/47 (78.72%) SI;ATP1B3;PIK3CA;...
Amphetamine addiction -1.99 2.87e-3 57/69 (82.61%) GRIN2C;PRKACA;PRKACG;...
Protein processing in endoplasmic reticulum -1.99 0.00e+0 127/171 (74.27%) DNAJB2;DERL2;NSFL1C;...
Glycine, serine and threonine metabolism -2.00 0.00e+0 31/40 (77.5%) BHMT;PHGDH;AMT;...
Ferroptosis -2.20 0.00e+0 36/41 (87.8%) PCBP2;GPX4;SLC3A2;...
Thyroid hormone synthesis -2.24 0.00e+0 66/75 (88%) GPX1;TPO;ATP1B3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H