Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCXRZF)

Drug Name
LY2603618 Drug Info
Synonyms
LY2603618; Rabusertib; 911222-45-2; LY 2603618; LY-2603618; UNII-3S9L1NU6U7; 3S9L1NU6U7; IC-83; ly2603618 IC-83; (S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea; n-(5-bromo-4-methyl-2-((2s)-2-morpholinylmethoxy)phenyl)-n'-(5-methyl-2-pyrazinyl)urea; LY2603618 (IC-83); Rabusertib [USAN:INN]; 3-(5-Bromo-4-methyl-2-[(2s)-morpholin-2-ylmethoxy]phenyl)-1-(5-methylpyrazin-2-yl)urea; N-[5-Bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy)phenyl]-N'-(5-methyl-2-pyrazinyl)urea
Cross-matching ID
PubChem CID
11955855
ChEBI ID
CHEMBL3039517
CAS Number
CAS 911222-45-2
TTD Drug ID
D00NZL
INTEDE Drug ID
DR1846

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.24 0.00e+0 19/20 (95%) SQLE;MSMO1;DHCR7;...
p53 signaling pathway 2.23 0.00e+0 63/73 (86.3%) CDKN1A;GADD45A;DDB2;...
Legionellosis 2.18 0.00e+0 51/57 (89.47%) NFKBIA;CXCL2;ITGAM;...
Influenza A 2.16 0.00e+0 156/172 (90.7%) NFKBIA;TNFRSF10B;FAS;...
NF-kappa B signaling pathway 2.11 0.00e+0 90/104 (86.54%) RELB;NFKBIA;GADD45A;...
Cytosolic DNA-sensing pathway 2.03 3.14e-3 52/63 (82.54%) NFKBIA;PYCARD;NFKB1;...
Osteoclast differentiation 1.95 2.69e-3 117/127 (92.13%) RELB;NFKBIA;FOSL1;...
RIG-I-like receptor signaling pathway 1.94 3.53e-3 64/70 (91.43%) NFKBIA;ISG15;NFKB1;...
Measles 1.91 4.18e-3 133/139 (95.68%) NFKBIA;TNFAIP3;FAS;...
Epstein-Barr virus infection 1.88 5.64e-3 189/202 (93.56%) CDKN1A;RELB;NFKBIA;...
Transcriptional misregulation in cancer 1.88 5.99e-3 158/192 (82.29%) CDKN1A;GADD45A;DUSP6;...
Terpenoid backbone biosynthesis 1.88 5.49e-3 18/22 (81.82%) HMGCS1;ACAT2;FDPS;...
Pertussis 1.85 6.51e-3 64/76 (84.21%) ITGAM;PYCARD;LY96;...
Toll-like receptor signaling pathway 1.82 1.01e-2 94/104 (90.38%) NFKBIA;LY96;FOS;...
Leishmaniasis 1.78 1.19e-2 67/77 (87.01%) NFKBIA;ITGAM;FOS;...
Toxoplasmosis 1.77 1.59e-2 103/112 (91.96%) NFKBIA;LDLR;LY96;...
Chronic myeloid leukemia 1.76 1.66e-2 72/76 (94.74%) CDKN1A;NFKBIA;GADD45A;...
Apoptosis 1.76 1.72e-2 126/168 (75%) NFKBIA;GADD45A;TNFRSF10B;...
TNF signaling pathway 1.75 1.73e-2 103/112 (91.96%) NFKBIA;JUNB;CXCL2;...
Hepatitis B 1.73 2.16e-2 151/162 (93.21%) CDKN1A;NFKBIA;EGR2;...
IL-17 signaling pathway 1.71 2.28e-2 84/94 (89.36%) NFKBIA;FOSL1;CXCL2;...
Small cell lung cancer 1.70 2.22e-2 90/92 (97.83%) CDKN1A;NFKBIA;GADD45A;...
Viral protein interaction with cytokine and cytokine re... 1.70 2.29e-2 84/100 (84%) CXCL2;TNFRSF10B;CCL2;...
Herpes simplex virus 1 infection 1.68 2.43e-2 165/498 (33.13%) NFKBIA;FAS;BAX;...
Cytokine-cytokine receptor interaction 1.68 2.37e-2 246/295 (83.39%) CXCL2;TNFRSF10B;IL32;...
Chagas disease 1.66 2.89e-2 93/102 (91.18%) NFKBIA;FAS;CCL2;...
Proteasome 1.64 3.34e-2 44/46 (95.65%) PSMA4;PSMD8;PSMB8;...
Rheumatoid arthritis 1.63 3.29e-2 78/93 (83.87%) CXCL2;CCL2;FOS;...
Viral carcinogenesis 1.62 3.70e-2 149/203 (73.4%) CDKN1A;NFKBIA;EGR2;...
Tuberculosis 1.60 4.28e-2 159/180 (88.33%) ITGAM;BAX;RFX5;...
Thyroid hormone synthesis -1.72 3.60e-2 66/75 (88%) LRP2;ALB;ADCY2;...
Gap junction -1.75 2.59e-2 72/88 (81.82%) NRAS;GRM5;ITPR1;...
Pentose and glucuronate interconversions -1.77 2.51e-2 17/34 (50%) CRYL1;UGT2B17;KL;...
Carbohydrate digestion and absorption -1.77 2.72e-2 37/47 (78.72%) AKT3;PIK3CA;SLC5A1;...
Adherens junction -1.83 1.06e-2 63/71 (88.73%) RHOA;CTNNA2;CTNNB1;...
Fanconi anemia pathway -1.92 4.23e-3 36/54 (66.67%) FANCC;RMI1;RPA2;...
Mismatch repair -1.96 5.29e-3 22/23 (95.65%) POLD3;LIG1;POLD2;...
Homologous recombination -1.99 7.05e-3 35/41 (85.37%) SEM1;RAD51B;MRE11;...
Nitrogen metabolism -2.00 1.06e-2 16/17 (94.12%) CA4;CA14;CA9;...
DNA replication -2.41 0.00e+0 34/36 (94.44%) RFC3;RPA2;FEN1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 3.33uM 24H
Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 3.33uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 3.33uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 3.33uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 3.33uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 3.33uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 3.33uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 3.33uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 3.33uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 3.33uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 3.33uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 3.33uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 3.33uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 3.33uM 24H
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 3.33uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 3.33uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H
Urinary bladder
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 3.33uM 24H