Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCY0TI)

Drug Name
Carglumic acid Drug Info
Synonyms Carbaglu (TN)
Cross-matching ID
PubChem CID
121396
ChEBI ID
CHEMBL71028
CAS Number
CAS 1188-38-1
TTD Drug ID
D0Z0MG
ACDINA Drug ID
D00916

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Complement and coagulation cascades 2.08 0.00e+0 76/85 (89.41%) C1QB;A2M;C7;...
Drug metabolism 1.85 1.44e-2 78/151 (51.66%) UGT2B4;ADH1B;DPYD;...
Fanconi anemia pathway 1.76 4.03e-2 36/54 (66.67%) RPA3;ATR;FANCL;...
Retinol metabolism 1.75 3.16e-2 41/68 (60.29%) HSD17B6;UGT2B4;ADH1B;...
Epithelial cell signaling in Helicobacter pylori infect... -1.75 4.62e-2 62/70 (88.57%) CXCR1;SRC;ADAM10;...
Chemokine signaling pathway -1.78 4.70e-2 163/192 (84.9%) CXCR1;SRC;CCR3;...
TNF signaling pathway -1.80 4.41e-2 103/112 (91.96%) MAP2K3;CX3CL1;CASP8;...
Cytokine-cytokine receptor interaction -1.90 4.90e-3 246/295 (83.39%) TNFRSF9;IL2RG;IL4;...
Pentose phosphate pathway -2.06 0.00e+0 25/30 (83.33%) H6PD;TKTL1;ALDOA;...
Viral protein interaction with cytokine and cytokine re... -2.07 0.00e+0 84/100 (84%) IL2RG;CXCR1;CCR3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H