Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCYVDT)

• Drug Name: Chlorzoxazone Drug Info
• Synonyms: Biomioran; CLW; Chloroxazone; Chlorsoxazone; Chlorzoxane; Chlorzoxazon; Chlorzoxazona; Chlorzoxazonum; Clorzoxazona; Escoflex; Klorzoxazon; Mioran; Miotran; Myoflexin; Myoflexine; Neoflex; Nyoflex; Paraflex; Parafon; Pathorysin; Relaxazone; Remofleks; Remular; Solaxin; Component of Parafon Forte; McNeil Brand of Chlorzoxazone; Ortho Brand of Chlorzoxazone; Parafon Forte; Parafon Forte DSC; Strifon Forte Dsc; C 4397; Chlorzoxazonum [INN-Latin]; Clorzoxazona [INN-Spanish]; EZE-DS; Muscol (TN); Paraflex (TN); Parafon Forte (TN); Remular-S; Usaf ma-10; Chlorzoxazone [INN:BAN:JAN]; Chlorzoxazone (JAN/USP/INN); 2-Hydroxy-5-chlorobenzoxazole; 5-Chlorbenzoxazolin-2-on; 5-Chloro-1,3-benzoxazol-2(3H)-one; 5-Chloro-2(3H)-benzoxazolone; 5-Chloro-2-benzoxazolinone; 5-Chloro-2-benzoxazolol; 5-Chloro-2-benzoxazolone; 5-Chloro-2-hydroxybenzoxazole; 5-Chloro-3(H)-2-benzoxazolone; 5-Chlorobenzoksazolinon-2; 5-Chlorobenzoksazolinon-2 [Polish]; 5-Chlorobenzoksazolon-2; 5-Chlorobenzoksazolon-2 [Polish]; 5-Chlorobenzoxazol-2-one; 5-Chlorobenzoxazolidone; 5-Chlorobenzoxazolone; 5-chloro-1,3-benzoxazol-2-ol; 5-chloro-3H-1,3-benzoxazol-2-one; 5-chlorobenzoxazolin-2-one
• Therapeutic Class: Analgesics
• Cross-matching ID:
  PubChem CID: 2733
  ChEBI ID: CHEMBL1371
  CAS Number: CAS 95-25-0
  TTD Drug ID: D08ZEB
  VARIDT Drug ID: DR00571
  INTEDE Drug ID: DR0312
  ACDINA Drug ID: D00127

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Prostate cancer	1.96	4.73e-2	93/97 (95.88%)	LEF1;PDGFC;MMP9;...
Protein digestion and absorption	1.87	3.31e-2	78/103 (75.73%)	COL15A1;COL16A1;COL11A1;...
Melanoma	1.84	2.52e-2	68/72 (94.44%)	CDH1;PDGFC;BAD;...
Focal adhesion	1.77	4.26e-2	180/201 (89.55%)	PDGFC;LAMB1;VWF;...
ECM-receptor interaction	1.75	4.73e-2	80/88 (90.91%)	LAMB1;VWF;AGRN;...
Biosynthesis of unsaturated fatty acids	-1.72	3.99e-2	21/27 (77.78%)	BAAT;ACAA1;HACD3;...
Sulfur metabolism	-1.73	3.87e-2	9/10 (90%)	TST;PAPSS1;MPST;...
Salivary secretion	-1.74	3.41e-2	76/93 (81.72%)	LPO;ATP1B2;MUC7;...
African trypanosomiasis	-1.83	1.07e-2	32/37 (86.49%)	IDO1;NPPA;ICAM1;...
Mineral absorption	-1.84	1.07e-2	48/60 (80%)	MT1H;SLC34A2;TRPV6;...
Phenylalanine metabolism	-1.85	1.07e-2	14/17 (82.35%)	GOT1;TAT;PAH;...
Histidine metabolism	-1.87	1.24e-2	16/22 (72.73%)	HAL;FTCD;ALDH1B1;...
Tryptophan metabolism	-1.87	1.49e-2	35/42 (83.33%)	IDO1;KYNU;ALDH1B1;...
Pyruvate metabolism	-1.88	1.86e-2	41/47 (87.23%)	FH;ACAT1;PKLR;...
Pantothenate and CoA biosynthesis	-1.91	1.78e-2	14/21 (66.67%)	PANK2;PANK3;ENPP1;...
Oxidative phosphorylation	-1.91	2.66e-2	93/133 (69.92%)	ATP5MC3;COX5A;ATP5PF;...
Steroid biosynthesis	-1.96	4.26e-2	19/20 (95%)	FDFT1;DHCR7;SOAT1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	24H	Hide ▲