Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMCZI62)

Drug Name
LORECLEZOLE Drug Info
Synonyms Loreclezole < Rec INN; R-72063; (Z)-1-(alpha,2,4-Trichlorostyryl)-1H-1,2,4-triazole; (Z)-1-[2-Chloro-2-(2,4-dichlorophenyl)vinyl]-1H-1,2,4-triazole
Cross-matching ID
PubChem CID
3034012
ChEBI ID
CHEMBL92491
CAS Number
CAS 117857-45-1
TTD Drug ID
D0H6PN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Allograft rejection 2.33 0.00e+0 32/38 (84.21%) HLA-DQA1;HLA-DPB1;HLA-DPA1;...
Type I diabetes mellitus 2.14 0.00e+0 38/43 (88.37%) HLA-DQA1;HLA-DPB1;HLA-DPA1;...
Autoimmune thyroid disease 2.04 0.00e+0 46/53 (86.79%) HLA-DQA1;HLA-DPB1;HLA-DPA1;...
Central carbon metabolism in cancer 1.99 0.00e+0 67/70 (95.71%) SIRT3;LDHB;MET;...
Viral myocarditis 1.95 6.06e-3 53/60 (88.33%) HLA-DQA1;HLA-DPB1;HLA-DPA1;...
Intestinal immune network for IgA production 1.94 7.58e-3 38/48 (79.17%) HLA-DQA1;HLA-DPB1;HLA-DPA1;...
Graft-versus-host disease 1.94 6.50e-3 32/42 (76.19%) HLA-DQA1;HLA-DPB1;HLA-DPA1;...
Antigen processing and presentation 1.91 5.68e-3 60/78 (76.92%) HLA-DQA1;HLA-DPB1;HLA-DPA1;...
Th17 cell differentiation 1.87 1.35e-2 95/107 (88.79%) HLA-DQA1;TGFBR2;HLA-DPB1;...
Small cell lung cancer 1.81 1.97e-2 90/92 (97.83%) CKS2;GADD45G;CDKN1B;...
Asthma 1.80 1.93e-2 25/31 (80.65%) HLA-DQA1;HLA-DPB1;HLA-DPA1;...
Chronic myeloid leukemia 1.77 2.65e-2 72/76 (94.74%) TGFBR2;MECOM;GADD45G;...
Fanconi anemia pathway 1.77 2.56e-2 36/54 (66.67%) MLH1;ATR;BLM;...
Glycolysis / Gluconeogenesis 1.72 3.79e-2 56/67 (83.58%) LDHB;ALDOA;PKM;...
Toxoplasmosis 1.71 3.94e-2 103/112 (91.96%) HLA-DQA1;HLA-DPB1;HLA-DPA1;...
HIF-1 signaling pathway 1.70 3.88e-2 105/109 (96.33%) LDHB;ALDOA;PFKFB3;...
Human T-cell leukemia virus 1 infection 1.70 4.01e-2 197/219 (89.95%) HLA-DQA1;TGFBR2;HLA-DPB1;...
Fatty acid elongation 1.69 4.29e-2 19/27 (70.37%) HACD1;ELOVL6;PPT1;...
Galactose metabolism 1.68 4.63e-2 26/31 (83.87%) UGP2;GALE;PFKM;...
T cell receptor signaling pathway 1.67 4.40e-2 93/104 (89.42%) PAK1;CD8A;RASGRP1;...
Th1 and Th2 cell differentiation 1.67 4.19e-2 80/92 (86.96%) HLA-DQA1;HLA-DPB1;HLA-DPA1;...
Colorectal cancer 1.67 4.00e-2 84/86 (97.67%) TGFBR2;AREG;MLH1;...
Epstein-Barr virus infection 1.66 4.68e-2 189/202 (93.56%) HLA-DQA1;HLA-DPB1;HLA-DPA1;...
Leishmaniasis 1.65 4.67e-2 67/77 (87.01%) HLA-DQA1;HLA-DPB1;HLA-DPA1;...
Inflammatory bowel disease 1.65 4.61e-2 58/65 (89.23%) HLA-DQA1;HLA-DPB1;HLA-DPA1;...
Carbohydrate digestion and absorption 1.65 4.43e-2 37/47 (78.72%) ATP1B3;AKT1;ATP1A1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H