General Information of Drug (ID: DMCZSP3)

Drug Name
5-methoxycarbonylamino-N-acetyltryptamine Drug Info
Synonyms
5-Methoxycarbonylamino-N-acetyltryptamine; GR 135531; 190277-13-5; 5-MCA-NAT; 5MCA-NAT; CHEMBL504585; methyl 3-(2-acetamidoethyl)-1H-indol-5-ylcarbamate; methyl N-[3-(2-acetamidoethyl)-1H-indol-5-yl]carbamate; Methyl {3-[2-(Acetylamino)ethyl]-1h-Indol-5-Yl}carbamate; Methyl [3-[2-(acetylamino)ethyl]-1H-indol-5-yl]carbamate; Tocris-0896; AC1N7T0H; GTPL3393; SCHEMBL4655625; CTK6J2921; CHEBI:93457; DTXSID70401560; MPZVHKLZCUEJFO-UHFFFAOYSA-N; MolPort-003-848-587; HMS3266P16; ZINC2567732; BN0231; BDBM50260394; PDSP2_001790
Cross-matching ID
PubChem CID
4284525
ChEBI ID
CHEMBL93457
CAS Number
CAS 190277-13-5
TTD Drug ID
D01LAU

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Spliceosome 1.89 6.96e-2 101/150 (67.33%) LSM2;PUF60;HSPA2;...
Proteasome 1.73 1.54e-1 44/46 (95.65%) PSMD2;PSMB8;IFNG;...
Proximal tubule bicarbonate reclamation 1.66 2.12e-1 21/23 (91.3%) CA2;SLC4A4;PCK1;...
Biosynthesis of unsaturated fatty acids 1.63 2.04e-1 21/27 (77.78%) ELOVL5;FADS1;ELOVL4;...
Glycosaminoglycan degradation 1.60 1.93e-1 19/19 (100%) HPSE;HGSNAT;NAGLU;...
Protein digestion and absorption 1.55 2.77e-1 78/103 (75.73%) SLC7A7;COL4A3;COL1A2;...
Cell adhesion molecules 1.50 3.84e-1 118/148 (79.73%) CDH2;JAM3;CADM1;...
Hematopoietic cell lineage 1.50 3.37e-1 90/99 (90.91%) ANPEP;TFRC;KIT;...
Pancreatic secretion 1.49 3.12e-1 87/102 (85.29%) CA2;SLC4A4;CD38;...
Arrhythmogenic right ventricular cardiomyopathy 1.44 4.30e-1 70/77 (90.91%) CDH2;DSP;SGCB;...
Viral protein interaction with cytokine and cytokine re... 1.43 4.13e-1 84/100 (84%) CCL19;CCL4;CCL8;...
Fatty acid elongation 1.43 3.84e-1 19/27 (70.37%) ELOVL5;ELOVL4;ACOT7;...
Mineral absorption 1.43 3.58e-1 48/60 (80%) MT1M;FTL;FXYD2;...
Insulin secretion 1.43 3.40e-1 75/86 (87.21%) STX1A;FXYD2;KCNN2;...
Primary immunodeficiency 1.42 3.40e-1 33/38 (86.84%) BTK;CD40;ICOS;...
Allograft rejection 1.40 3.47e-1 32/38 (84.21%) IFNG;CD40;TNF;...
Bile secretion 1.40 3.36e-1 68/90 (75.56%) CA2;UGT2B28;SLC4A4;...
NF-kappa B signaling pathway 1.40 3.19e-1 90/104 (86.54%) CCL19;BTK;BCL2A1;...
Salivary secretion 1.38 3.51e-1 76/93 (81.72%) CALML5;CD38;FXYD2;...
Inflammatory bowel disease 1.38 3.47e-1 58/65 (89.23%) GATA3;SMAD2;STAT1;...
Asthma 1.36 3.54e-1 25/31 (80.65%) CD40;TNF;IL9;...
Vitamin digestion and absorption 1.35 3.58e-1 17/24 (70.83%) SLC19A2;LMBRD1;PNLIP;...
Selenocompound metabolism 1.35 3.67e-1 11/17 (64.71%) CTH;KYAT3;SEPHS2
Renin-angiotensin system 1.34 3.71e-1 20/23 (86.96%) ANPEP;AGTR1;KLK1;...
Transcriptional misregulation in cancer 1.34 3.61e-1 158/192 (82.29%) BCL2A1;MMP9;MYCN;...
Intestinal immune network for IgA production 1.32 4.01e-1 38/48 (79.17%) CD40;ICOS;CXCL12;...
Systemic lupus erythematosus 1.31 3.95e-1 45/135 (33.33%) IFNG;C7;CD40;...
Endocrine and other factor-regulated calcium reabsorpti... 1.31 3.88e-1 49/53 (92.45%) AP2M1;FXYD2;PRKCB;...
Epstein-Barr virus infection 1.30 4.08e-1 189/202 (93.56%) CYCS;BTK;PSMD2;...
Cortisol synthesis and secretion 1.27 4.72e-1 58/65 (89.23%) CYP11A1;ITPR3;AGTR1;...
Alanine, aspartate and glutamate metabolism -1.10 7.28e-1 27/37 (72.97%) ASPA;GOT2;GLS2;...
Non-homologous end-joining -1.11 7.19e-1 11/13 (84.62%) LIG4;POLL;RAD50;...
Human papillomavirus infection -1.11 7.02e-1 284/331 (85.8%) CCND1;PPP2R3A;LAMC1;...
Renin secretion -1.12 6.95e-1 61/69 (88.41%) PLCB4;PLCB2;ITPR1;...
Wnt signaling pathway -1.12 7.06e-1 124/166 (74.7%) RAC2;CCND1;TBL1XR1;...
Signaling pathways regulating pluripotency of stem cell... -1.12 7.02e-1 110/143 (76.92%) PCGF2;BMPR2;ACVR2B;...
Fat digestion and absorption -1.13 7.03e-1 35/43 (81.4%) PLA2G10;ABCA1;ACAT1;...
Pantothenate and CoA biosynthesis -1.13 7.11e-1 14/21 (66.67%) BCAT1;PANK3;ALDH3A2;...
Salmonella infection -1.13 7.22e-1 198/249 (79.52%) RPS3;TCF7;GSDMD;...
Glycerolipid metabolism -1.13 7.26e-1 44/61 (72.13%) ALDH3A2;AGPAT3;LIPC;...
Neurotrophin signaling pathway -1.14 7.21e-1 107/119 (89.92%) RAP1A;CAMK2B;RPS6KA3;...
Tight junction -1.14 7.23e-1 130/169 (76.92%) CLDN8;PPP2CA;PARD6A;...
Vasopressin-regulated water reabsorption -1.15 7.07e-1 40/44 (90.91%) DCTN4;CREB3L1;RAB5B;...
PI3K-Akt signaling pathway -1.15 7.16e-1 317/354 (89.55%) ATF2;CCND1;PPP2R3A;...
TNF signaling pathway -1.15 7.21e-1 103/112 (91.96%) CEBPB;ATF2;IKBKG;...
Malaria -1.21 7.22e-1 44/50 (88%) SDC1;ITGB2;TGFB3;...
Osteoclast differentiation -1.21 7.24e-1 117/127 (92.13%) PIK3R1;MAPK14;MAP2K1;...
Adherens junction -1.22 7.03e-1 63/71 (88.73%) SORBS1;RAC2;TCF7L1;...
Autophagy -1.22 7.17e-1 113/169 (66.86%) STX17;SQSTM1;IGBP1;...
FoxO signaling pathway -1.23 7.27e-1 118/131 (90.08%) MDM2;TGFB2;CAT;...
Epithelial cell signaling in Helicobacter pylori infect... -1.25 6.66e-1 62/70 (88.57%) IKBKG;CXCR1;CASP3;...
Colorectal cancer -1.25 6.86e-1 84/86 (97.67%) TGFB2;RAC2;CCND1;...
Hedgehog signaling pathway -1.25 7.07e-1 43/56 (76.79%) GLI3;CSNK1G1;PTCH1;...
Estrogen signaling pathway -1.25 7.26e-1 119/137 (86.86%) KRT20;RARA;ATF2;...
Axon guidance -1.47 6.73e-1 151/182 (82.97%) ABL1;NCK1;BMPR2;...
Fc gamma R-mediated phagocytosis -1.58 3.50e-1 79/97 (81.44%) ARPC3;ARF6;ASAP3;...
Glyoxylate and dicarboxylate metabolism -1.61 3.47e-1 23/30 (76.67%) CAT;HYI;DLD;...
One carbon pool by folate -1.69 2.11e-1 15/20 (75%) AMT;ALDH1L1;GART;...
Mucin type O-glycan biosynthesis -1.73 2.11e-1 20/36 (55.56%) C1GALT1;ST3GAL2;B3GNT3;...
Other types of O-glycan biosynthesis -1.82 1.10e-1 29/47 (61.7%) GALNT11;PLOD3;OGT;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H