Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMD2WPG)

Drug Name
TRIENTINE Drug Info
Synonyms
Trientine HCl; 21121-06-2; triethylenetetramine HCl; SMR000058543; AC1NUQ0M; MLS000069683; SCHEMBL205201; CHEMBL1200783; CTK0I9735; DTXSID80419994; XPVOJYDIBHYVFL-UHFFFAOYSA-N; Pharmakon1600-01505675; NSC759164; NSC158271; AKOS027276425; NSC-158271; NSC-759164; 1, N,N'-bis(2-aminoethyl)-, tetrahydrochloride; 1,2-Ethanediamine, N,N'-bis(2-aminoethyl)-, hydrochloride; N'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine hydrochloride
Cross-matching ID
PubChem CID
5565
ChEBI ID
CHEMBL609
CAS Number
CAS 112-24-3
TTD Drug ID
D09VAZ
ACDINA Drug ID
D00702

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 1.87 3.48e-2 34/36 (94.44%) FEN1;MCM3;MCM5;...
Homologous recombination 1.85 1.74e-2 35/41 (85.37%) MRE11;BLM;PALB2;...
Cysteine and methionine metabolism 1.84 1.45e-2 43/50 (86%) ADI1;LDHB;DNMT3A;...
Thiamine metabolism 1.83 1.52e-2 12/15 (80%) AK4;AK1;TPK1;...
Mineral absorption 1.76 3.48e-2 48/60 (80%) MT1E;MT1F;MT1M;...
Mucin type O-glycan biosynthesis 1.73 4.93e-2 20/36 (55.56%) GCNT1;GALNT6;C1GALT1;...
IL-17 signaling pathway -1.82 3.62e-2 84/94 (89.36%) DEFB4A;MAPK6;CCL20;...
Notch signaling pathway -1.83 3.20e-2 49/59 (83.05%) EP300;DLL3;CTBP1;...
MicroRNAs in cancer -1.83 4.00e-2 146/310 (47.1%) CD44;CCND2;PTEN;...
Prostate cancer -1.85 3.42e-2 93/97 (95.88%) TMPRSS2;PTEN;PIK3R2;...
Primary immunodeficiency -1.90 2.28e-2 33/38 (86.84%) IGLL1;RAG2;RAG1;...
Ribosome -1.98 3.42e-2 113/158 (71.52%) RPS18;RPL37A;RPS14;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H