Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMD308S)

Drug Name
Pyrazinoylguanidine Drug Info
Synonyms PZG
Cross-matching ID
PubChem CID
124704
CAS Number
CAS 60398-24-5
TTD Drug ID
D0W9PG

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Fanconi anemia pathway 2.14 0.00e+0 36/54 (66.67%) FANCG;PALB2;ATR;...
Ribosome biogenesis in eukaryotes 1.76 3.44e-2 52/108 (48.15%) NVL;POP5;IMP4;...
Cell cycle 1.75 2.97e-2 110/124 (88.71%) CDKN1B;TGFB3;CDC7;...
Gap junction -1.63 3.65e-2 72/88 (81.82%) GJA1;ADCY2;TUBB;...
Asthma -1.64 3.57e-2 25/31 (80.65%) IL9;CD40LG;HLA-DMB;...
Systemic lupus erythematosus -1.65 3.52e-2 45/135 (33.33%) IL10;C1S;FCGR2A;...
Glucagon signaling pathway -1.65 3.62e-2 89/107 (83.18%) ADCY2;GCG;PPP4R3A;...
Toxoplasmosis -1.66 3.60e-2 103/112 (91.96%) TYK2;PIK3R5;BAD;...
Complement and coagulation cascades -1.66 3.63e-2 76/85 (89.41%) C1QA;SERPINB2;FGA;...
Th17 cell differentiation -1.66 3.52e-2 95/107 (88.79%) IL6ST;CD3G;IL21;...
Fructose and mannose metabolism -1.67 3.64e-2 30/33 (90.91%) ALDOA;GMDS;ALDOC;...
Pentose phosphate pathway -1.71 2.95e-2 25/30 (83.33%) TALDO1;ALDOA;ALDOC;...
Antigen processing and presentation -1.71 2.95e-2 60/78 (76.92%) PSME1;CD74;HSP90AA1;...
Aldosterone-regulated sodium reabsorption -1.72 3.10e-2 34/37 (91.89%) ATP1B2;KCNJ1;SFN;...
Leukocyte transendothelial migration -1.72 3.19e-2 90/114 (78.95%) CXCL12;RAC2;PXN;...
Cocaine addiction -1.73 3.06e-2 42/49 (85.71%) CREB3;PRKACB;SLC18A2;...
Fc gamma R-mediated phagocytosis -1.74 2.92e-2 79/97 (81.44%) CDC42;MARCKSL1;PLD1;...
Cell adhesion molecules -1.75 2.58e-2 118/148 (79.73%) ITGB8;NRXN3;CDH3;...
Inflammatory bowel disease -1.75 2.67e-2 58/65 (89.23%) IL21;HLA-DMB;IL10;...
Th1 and Th2 cell differentiation -1.75 2.76e-2 80/92 (86.96%) MAPK14;MAPK8;CD247;...
Toll-like receptor signaling pathway -1.80 1.70e-2 94/104 (90.38%) MAP2K3;CD80;TICAM1;...
Renin-angiotensin system -1.81 1.61e-2 20/23 (86.96%) REN;ANPEP;AGT;...
Intestinal immune network for IgA production -1.83 1.38e-2 38/48 (79.17%) CCR10;CD40LG;HLA-DMB;...
Type I diabetes mellitus -1.86 8.27e-3 38/43 (88.37%) HLA-DOA;HLA-DOB;CD80;...
HIF-1 signaling pathway -1.86 7.66e-3 105/109 (96.33%) IFNG;GAPDH;LDHC;...
Central carbon metabolism in cancer -1.86 6.89e-3 67/70 (95.71%) IDH2;IDH1;LDHC;...
Allograft rejection -1.87 7.88e-3 32/38 (84.21%) HLA-C;CD40LG;HLA-DMB;...
Citrate cycle (TCA cycle) -1.91 2.30e-3 30/30 (100%) IDH2;IDH1;OGDHL;...
Proximal tubule bicarbonate reclamation -1.96 2.76e-3 21/23 (91.3%) SLC4A4;SLC25A10;ATP1B2;...
Ferroptosis -2.04 0.00e+0 36/41 (87.8%) GCLC;TP53;PRNP;...
Graft-versus-host disease -2.04 0.00e+0 32/42 (76.19%) HLA-DOA;KLRD1;KIR2DL3;...
Steroid biosynthesis -2.08 0.00e+0 19/20 (95%) TM7SF2;DHCR24;EBP;...
Glycolysis / Gluconeogenesis -2.39 0.00e+0 56/67 (83.58%) ADH1C;GAPDH;LDHC;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H