Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMD3BEQ)

Drug Name
ERIODICTYOL Drug Info
Synonyms
(+/-)-Eriodictyol; 4049-38-1; MLS000877024; 5,7,3',4'-Tetrahydroxyflavanone; 2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-4-one; 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chroman-4-one; SMR000440624; 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-; 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one; Eriodictyol, (+/-)-; Eriodicytol; ERIODYCTOL; Flavanone, 3',4',5,7-tetrahydroxy-; AC1L1WLT
Cross-matching ID
PubChem CID
440735
ChEBI ID
CHEMBL8996
CAS Number
CAS 552-58-9
TTD Drug ID
D08AIJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Folate biosynthesis 1.92 0.00e+0 23/26 (88.46%) GGH;AKR1B10;AKR1C3;...
Staphylococcus aureus infection 1.88 9.89e-3 72/95 (75.79%) C1QA;HLA-DQA1;KRT14;...
Cysteine and methionine metabolism 1.84 1.65e-2 43/50 (86%) BCAT1;CDO1;GCLM;...
Ferroptosis 1.82 2.23e-2 36/41 (87.8%) HMOX1;SLC39A8;GCLM;...
One carbon pool by folate 1.79 2.77e-2 15/20 (75%) MTHFD1;MTHFD2;ALDH1L1;...
Parkinson disease 1.77 3.13e-2 176/249 (70.68%) GNAS;CALML3;UCHL1;...
Tyrosine metabolism 1.73 4.95e-2 30/36 (83.33%) ADH5;ADH1C;ALDH3A1;...
Steroid biosynthesis 1.72 4.58e-2 19/20 (95%) DHCR24;MSMO1;CYP51A1;...
Pantothenate and CoA biosynthesis 1.72 4.73e-2 14/21 (66.67%) BCAT1;ALDH3A2;ENPP1;...
Thermogenesis 1.72 4.35e-2 173/232 (74.57%) FGFR1;GNAS;ACSL5;...
Viral protein interaction with cytokine and cytokine re... 1.71 3.96e-2 84/100 (84%) CXCL14;ACKR3;CXCL13;...
Endometrial cancer -1.98 1.01e-2 56/58 (96.55%) ILK;GRB2;CASP9;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.2uM - 25uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.2uM - 25uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H