Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMD4381)

• Drug Name: Terbutaline Drug Info
• Synonyms: Asthmasian; Brethaire; Brethine; Brican; Bricanyl; Bricar; Bricaril; Bricyn; Terbutalin; Terbutalina; Terbutalino; Terbutalinum; Terbutalina [DCIT]; Terbutaline sulfate; KWD 2019; Asthmasian (TN); Brethaire (TN); Brethine (TN); Bricanyl (TN); KWD-2019; Terbutaline (INN); Terbutaline [INN:BAN]; Terbutalino [INN-Spanish]; Terbutalinum [INN-Latin]; (+-)-5-(2-((1,1-Dimethylethyl)amino)-1-hydroxyethyl)-1,3-benzenediol; (+-)-Terbutaline; 1,3-Benzenediol, 5-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-(9CI); 5-(2-((1,1-DIMETHYLETHYL)AMINO)-1-HYDROXYETHYL)-1,3-BENZENEDIOL; 5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol; 5-{2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl}benzene-1,3-diol
• Therapeutic Class: Bronchodilator Agents
• Cross-matching ID:
  PubChem CID: 5403
  ChEBI ID: CHEMBL9449
  CAS Number: CAS 23031-25-6
  TTD Drug ID: D0M8RC
  VARIDT Drug ID: DR00971
  ACDINA Drug ID: D00664

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Cell cycle	1.94	2.18e-2	110/124 (88.71%)	SMC1A;PLK1;ORC1;...
RNA degradation	1.86	2.91e-2	53/79 (67.09%)	TOB1;TOB2;CNOT4;...
Progesterone-mediated oocyte maturation	1.74	4.94e-2	75/100 (75%)	PLK1;CDK2;PIK3CA;...
DNA replication	1.73	4.73e-2	34/36 (94.44%)	FEN1;PRIM1;MCM2;...
Ribosome	-1.80	2.39e-2	113/158 (71.52%)	RPL17;RPL28;RPL13A;...
Primary bile acid biosynthesis	-1.83	1.04e-2	15/17 (88.24%)	CH25H;ACOT8;CYP46A1;...
Biosynthesis of unsaturated fatty acids	-1.84	1.31e-2	21/27 (77.78%)	HACD1;ELOVL2;ACAA1;...
B cell receptor signaling pathway	-1.85	1.74e-2	71/81 (87.65%)	RAC1;LILRA1;CD19;...
Arginine biosynthesis	-2.04	0.00e+0	17/22 (77.27%)	GLS2;OTC;ARG2;...
Steroid biosynthesis	-2.11	0.00e+0	19/20 (95%)	LSS;NSDHL;CYP51A1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼