Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMD4N2F)

Drug Name
Devazepide Drug Info
Synonyms
DEVAZEPIDE; 103420-77-5; MK-329; Devazepidum; Devazepida; MK 329; L-364,718; UNII-JE6P7QY7NH; L 364718; (S)-N-(2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)indole-2-carboxamide; JE6P7QY7NH; CHEMBL9506; CHEBI:4460; L-364718; 3(S)-(-)-1,3-Dihydro-3-(2-indolecarbonylamino)-1-methyl-5-phenyl-2H-(1,4)benzodiazepin-2-one; NCGC00159551-01; DSSTox_RID_81331; DSSTox_CID_26092; DSSTox_GSID_46092; 1H-Indole-2-carboxamide,
Cross-matching ID
PubChem CID
443375
ChEBI ID
CHEMBL9506
CAS Number
CAS 103420-77-5
TTD Drug ID
D05QBF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Legionellosis 2.26 0.00e+0 51/57 (89.47%) HSPA1A;HSPA8;CXCL8;...
Protein processing in endoplasmic reticulum 2.20 0.00e+0 127/171 (74.27%) HSPA1A;HSPA8;HERPUD1;...
Antigen processing and presentation 2.11 5.05e-3 60/78 (76.92%) HSPA1A;HSPA8;HSPA5;...
Ferroptosis 2.00 3.78e-3 36/41 (87.8%) HMOX1;GCLM;SLC7A11;...
Mitophagy 1.99 3.03e-3 56/68 (82.35%) SRC;SQSTM1;EIF2AK3;...
Fluid shear stress and atherosclerosis 1.92 5.05e-3 123/139 (88.49%) HMOX1;SRC;SQSTM1;...
Viral myocarditis 1.86 1.51e-2 53/60 (88.33%) HLA-B;ITGB2;ACTB;...
Mineral absorption 1.83 2.08e-2 48/60 (80%) HMOX1;MT1E;FTL;...
Estrogen signaling pathway 1.80 2.69e-2 119/137 (86.86%) HSPA1A;HSPA8;SRC;...
Kaposi sarcoma-associated herpesvirus infection 1.78 2.72e-2 172/193 (89.12%) CDKN1A;CXCL8;SRC;...
IL-17 signaling pathway 1.76 2.75e-2 84/94 (89.36%) CXCL8;FOSL1;TNFAIP3;...
HIF-1 signaling pathway 1.76 2.78e-2 105/109 (96.33%) HMOX1;CDKN1A;PFKP;...
Bacterial invasion of epithelial cells 1.75 2.91e-2 59/77 (76.62%) SRC;CRK;CLTB;...
Endocytosis 1.74 2.70e-2 198/252 (78.57%) HSPA1A;HSPA8;SRC;...
Bladder cancer 1.73 3.03e-2 40/41 (97.56%) CDKN1A;CXCL8;SRC;...
Measles 1.73 2.93e-2 133/139 (95.68%) HSPA1A;HSPA8;TNFAIP3;...
Human cytomegalovirus infection 1.69 4.90e-2 201/225 (89.33%) CDKN1A;CXCL8;SRC;...
Neurotrophin signaling pathway 1.69 4.63e-2 107/119 (89.92%) CRK;CALML5;SH2B3;...
Lipid and atherosclerosis 1.68 4.46e-2 190/215 (88.37%) HSPA1A;HSPA8;CXCL8;...
Pertussis 1.67 4.54e-2 64/76 (84.21%) CXCL8;ITGB2;CALML5;...
Necroptosis 1.67 4.76e-2 113/159 (71.07%) SQSTM1;TNFAIP3;DNM1L;...
Osteoclast differentiation 1.67 4.61e-2 117/127 (92.13%) FOSL1;SQSTM1;TREM2;...
Propanoate metabolism -1.58 4.90e-2 30/34 (88.24%) SUCLA2;MMUT;ABAT;...
Glyoxylate and dicarboxylate metabolism -1.66 2.68e-2 23/30 (76.67%) MMUT;AGXT;DLD;...
Oocyte meiosis -1.68 2.15e-2 90/129 (69.77%) ANAPC5;PKMYT1;ADCY1;...
Pyruvate metabolism -1.71 1.68e-2 41/47 (87.23%) ADH1A;ADH6;ALDH3A2;...
Valine, leucine and isoleucine degradation -1.74 1.32e-2 42/48 (87.5%) MCCC2;MCCC1;MMUT;...
Progesterone-mediated oocyte maturation -1.75 1.29e-2 75/100 (75%) PDE3B;ANAPC5;PKMYT1;...
One carbon pool by folate -1.75 1.37e-2 15/20 (75%) MTHFS;ATIC;TYMS;...
Non-homologous end-joining -1.76 1.47e-2 11/13 (84.62%) RAD50;XRCC5;DCLRE1C;...
Cell cycle -1.78 1.52e-2 110/124 (88.71%) TFDP1;RBL1;STAG1;...
Sulfur metabolism -1.78 1.68e-2 9/10 (90%) PAPSS2;SQOR;SELENBP1;...
Nucleotide excision repair -1.87 6.72e-3 40/47 (85.11%) CETN2;POLE;RBX1;...
Mismatch repair -1.88 7.00e-3 22/23 (95.65%) POLD3;MSH2;LIG1;...
Fatty acid degradation -1.90 3.74e-3 40/43 (93.02%) CPT1A;ACADS;ADH1A;...
Homologous recombination -1.98 2.80e-3 35/41 (85.37%) SSBP1;BABAM1;POLD1;...
DNA replication -2.03 0.00e+0 34/36 (94.44%) MCM3;POLD3;FEN1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H