Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMD59GI)

Drug Name
Urapidil Drug Info
Synonyms
urapidil; 34661-75-1; Ebrantil; Eupressyl; Mediatensyl; Uraprene; Urapidilum [INN-Latin]; UNII-A78GF17HJS; NSC 310405; B-66256; C20H29N5O3; EINECS 252-130-4; BRN 0725782; A78GF17HJS; MLS003115907; 6-(3-(4-(o-Methoxyphenyl)-1-piperazinyl)propylamino)-1,3-dimethyluracil; 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil; NCGC00016066-07; Ebrantil (TN); 6-((3-(4-(o-Methoxyphenyl)-1-piperazinyl)propyl)amino)-1,3-dimethyluracil; W-106718; Urapidilum; urapidil(jan); TgAAV-TNFR:Fc
Cross-matching ID
PubChem CID
5639
ChEBI ID
CHEMBL279229
CAS Number
CAS 34661-75-1
TTD Drug ID
D0K0VO

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.58 0.00e+0 34/36 (94.44%) PCNA;MCM2;MCM4;...
Spliceosome 2.32 0.00e+0 101/150 (67.33%) HSPA8;SNRPB;TRA2B;...
Cell cycle 2.26 0.00e+0 110/124 (88.71%) PCNA;SMC1A;MCM2;...
Mismatch repair 2.12 0.00e+0 22/23 (95.65%) PCNA;RFC5;POLD2;...
Base excision repair 2.04 0.00e+0 29/33 (87.88%) PCNA;POLE2;FEN1;...
Systemic lupus erythematosus 1.89 6.70e-3 45/135 (33.33%) C1QA;SNRPB;C3;...
Staphylococcus aureus infection 1.81 1.44e-2 72/95 (75.79%) C1QA;KRT18;KRT17;...
Nucleotide excision repair 1.71 4.92e-2 40/47 (85.11%) PCNA;RAD23B;POLE2;...
Phagosome 1.69 4.83e-2 118/152 (77.63%) SFTPA2;CD14;TUBB;...
Citrate cycle (TCA cycle) 1.68 4.84e-2 30/30 (100%) MDH1;IDH3B;IDH2;...
Lysosome -1.69 4.82e-2 115/128 (89.84%) CTSW;AP1M2;CLTB;...
IL-17 signaling pathway -1.70 4.64e-2 84/94 (89.36%) MMP3;MAPK10;NFKBIA;...
Epithelial cell signaling in Helicobacter pylori infect... -1.71 4.25e-2 62/70 (88.57%) HBEGF;ATP6V0C;MAPK10;...
Nicotinate and nicotinamide metabolism -1.71 4.58e-2 25/35 (71.43%) PNP;NT5C2;ENPP1;...
Viral protein interaction with cytokine and cytokine re... -1.72 4.75e-2 84/100 (84%) IL2RG;IL6R;IL6ST;...
Rheumatoid arthritis -1.74 4.23e-2 78/93 (83.87%) ATP6V0C;MMP3;IL15;...
Glycine, serine and threonine metabolism -1.76 3.55e-2 31/40 (77.5%) GAMT;AGXT;ALDH7A1;...
Histidine metabolism -1.78 3.48e-2 16/22 (72.73%) ALDH7A1;MAOB;MAOA;...
Metabolism of xenobiotics by cytochrome P450 -1.81 2.59e-2 49/77 (63.64%) GSTM1;AKR7A3;ADH5;...
TNF signaling pathway -2.02 0.00e+0 103/112 (91.96%) MMP3;MAPK10;ITCH;...
NF-kappa B signaling pathway -2.04 0.00e+0 90/104 (86.54%) NFKBIA;CARD10;BCL2A1;...
Steroid biosynthesis -2.06 0.00e+0 19/20 (95%) FDFT1;LIPA;DHCR7;...
Mineral absorption -2.30 0.00e+0 48/60 (80%) ATP2B1;MT1E;SLC30A1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H