Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMD5JYQ)

Drug Name
ZM-336372 Drug Info
Synonyms
ZM 336372; 208260-29-1; ZM336372; ZM-336372; 3-(dimethylamino)-N-(3-(4-hydroxybenzamido)-4-methylphenyl)benzamide; N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide; CHEMBL186526; n-(5-(3-dimethylaminobenzamido)-2-methylphenyl)-4-hydroxybenzamide; 3-(dimethylamino)-N-{3-[(4-hydroxybenzoyl)amino]-4-methylphenyl}benzamide; 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]benzamide; 3-(dimethylamino)-N-[3-(4-hydroxybenzamido)-4-methylphenyl]benzamide; Bio1_001346; compound 1 [PMID: 15454231
Cross-matching ID
PubChem CID
5730
ChEBI ID
CHEMBL186526
CAS Number
CAS 208260-29-1
TTD Drug ID
D00NWF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
AGE-RAGE signaling pathway in diabetic complications 2.20 0.00e+0 97/100 (97%) CCL2;VEGFC;TGFBR2;...
Pyrimidine metabolism 2.12 0.00e+0 40/56 (71.43%) NT5E;CDA;UPP1;...
Focal adhesion 2.01 0.00e+0 180/201 (89.55%) MET;PXN;CAV2;...
Purine metabolism 1.97 3.16e-3 102/129 (79.07%) NT5E;PDE9A;AK1;...
ECM-receptor interaction 1.88 1.01e-2 80/88 (90.91%) LAMB1;LAMC2;LAMB3;...
Amoebiasis 1.81 3.16e-2 99/102 (97.06%) LAMB1;LAMC2;LAMB3;...
Leukocyte transendothelial migration 1.79 3.43e-2 90/114 (78.95%) PXN;CYBA;CLDN4;...
Bacterial invasion of epithelial cells 1.76 4.27e-2 59/77 (76.62%) MET;PXN;CAV2;...
Sulfur metabolism 1.76 3.93e-2 9/10 (90%) ETHE1;SQOR;PAPSS1;...
Tight junction 1.72 4.68e-2 130/169 (76.92%) JUN;EPB41L4B;ARPC1A;...
RNA transport -1.69 4.45e-2 128/186 (68.82%) PAIP1;SEC13;NCBP1;...
Protein processing in endoplasmic reticulum -1.74 2.54e-2 127/171 (74.27%) SEC63;SEC62;HYOU1;...
mRNA surveillance pathway -1.74 2.86e-2 71/98 (72.45%) SMG1;ACIN1;NXF2;...
Longevity regulating pathway -1.78 2.16e-2 90/151 (59.6%) TSC2;IGF1R;ADIPOR2;...
PPAR signaling pathway -1.97 0.00e+0 66/74 (89.19%) ACSL6;ACSL1;APOA1;...
Terpenoid backbone biosynthesis -2.07 0.00e+0 18/22 (81.82%) MVK;ACAT2;MVD;...
Spliceosome -2.13 0.00e+0 101/150 (67.33%) TRA2B;HNRNPM;AQR;...
Steroid biosynthesis -2.34 0.00e+0 19/20 (95%) HSD17B7;NSDHL;FDFT1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 100uM 6H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 12.5uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 100uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 100uM 6H
HT-29 CVCL_0320 Homo sapiens 0.04uM - 100uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 100uM 6H
MDST8 CVCL_1400 Homo sapiens 100uM 6H
NCI-H508 CVCL_1561 Homo sapiens 100uM 6H
SNU-1040 CVCL_5001 Homo sapiens 100uM 6H
SNU-C4 CVCL_5008 Homo sapiens 100uM 6H
SNU-C5 CVCL_5009 Homo sapiens 100uM 6H
SW480 CVCL_0546 Homo sapiens 100uM 6H
SW620 CVCL_0547 Homo sapiens 100uM 6H
SW948 CVCL_0550 Homo sapiens 100uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 100uM 6H
HT115 CVCL_1294 Homo sapiens 100uM 6H
RKO CVCL_0504 Homo sapiens 100uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 100uM 6H
SNG-M CVCL_1707 Homo sapiens 100uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 100uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 100uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 100uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 100uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 100uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 100uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 100uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 100uM 6H
T3M-10 CVCL_1729 Homo sapiens 100uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 100uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 100uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 100uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 100uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 100uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 100uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 100uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 100uM 6H
OV7 CVCL_1623 Homo sapiens 100uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 100uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 100uM 6H
RMUG-S CVCL_1666 Homo sapiens 100uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 100uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 100uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 100uM 6H
PL-21 CVCL_2161 Homo sapiens 100uM 6H
SKM-1 CVCL_0010 Homo sapiens 100uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 100uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 100uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 100uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 100uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 100uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 100uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 100uM 6H