Details of the Drug Pharmacogenomic Perturbation Atlas

Ranirestat Drug Info

Cross-matching ID

PubChem CID

153948

ChEBI ID

CHEMBL334830

CAS Number

CAS 147254-64-6

TTD Drug ID

D0K8TI

General Information of Drug (ID: DMD5QRS)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Systemic lupus erythematosus	2.05	8.05e-3	45/135 (33.33%)	C1R;HLA-DQA1;C1S;...
Complement and coagulation cascades	2.03	8.05e-3	76/85 (89.41%)	C1R;PLAT;CFI;...
Staphylococcus aureus infection	1.93	1.34e-2	72/95 (75.79%)	KRT19;C1R;HLA-DQA1;...
Drug metabolism	1.82	2.82e-2	78/151 (51.66%)	ALDH3A1;FMO5;ADH1C;...
Steroid hormone biosynthesis	1.78	3.22e-2	43/61 (70.49%)	AKR1C3;CYP1A1;HSD17B6;...
Proteasome	1.77	3.35e-2	44/46 (95.65%)	PSMB8;PSMB9;PSMB4;...
Porphyrin and chlorophyll metabolism	1.75	3.22e-2	23/43 (53.49%)	HMOX1;BLVRB;HEPH;...
Metabolism of xenobiotics by cytochrome P450	1.75	2.92e-2	49/77 (63.64%)	ALDH3A1;CYP1A1;ADH1C;...
Tyrosine metabolism	1.71	3.58e-2	30/36 (83.33%)	ALDH3A1;ADH1C;GSTZ1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Ewing sarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
SK-ES-1	CVCL_0627	Homo sapiens	1.11uM - 10uM	24H

Brain

Glioma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
GI-1	CVCL_1230	Homo sapiens	1.11uM - 10uM	24H

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MDA-MB-468	CVCL_0419	Homo sapiens	1.11uM - 10uM	24H

Breast ductal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
T-47D	CVCL_0553	Homo sapiens	1.11uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
SNU-407	CVCL_5004	Homo sapiens	1.11uM - 10uM	24H

Endometrium

Endometrial adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
HEC-108	CVCL_2926	Homo sapiens	1.11uM - 10uM	24H

HEC-1-A	CVCL_0293	Homo sapiens	1.11uM - 10uM	24H

HEC-251	CVCL_2928	Homo sapiens	1.11uM - 10uM	24H

HEC-265	CVCL_2929	Homo sapiens	1.11uM - 10uM	24H

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
CJM	CVCL_U797	Homo sapiens	1.11uM - 10uM	24H

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
JHH-5	CVCL_1320	Homo sapiens	1.11uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
NCI-H1573	CVCL_1483	Homo sapiens	1.11uM - 10uM	24H

NCI-H838	CVCL_1594	Homo sapiens	1.11uM - 10uM	24H

Lung squamous cell carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
BEN	CVCL_1081	Homo sapiens	1.11uM - 10uM	24H

HCC95	CVCL_1276	Homo sapiens	1.11uM - 10uM	24H

Muscle

Rhabdomyosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-204	CVCL_0134	Homo sapiens	1.11uM - 10uM	24H

Ovary

Ovarian clear cell carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
OVTOKO	CVCL_3114	Homo sapiens	1.11uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
22Rv1	CVCL_1045	Homo sapiens	1.11uM - 10uM	24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
IGR-37	CVCL_1303	Homo sapiens	1.11uM - 10uM	24H

Mel-HO	CVCL_1402	Homo sapiens	1.11uM - 10uM	24H

SH-4	CVCL_1692	Homo sapiens	1.11uM - 10uM	24H

Urinary bladder

Bladder carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
BC-3C	CVCL_1079	Homo sapiens	1.11uM - 10uM	24H

Bladder transitional cell carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
CAL-29	CVCL_1109	Homo sapiens	1.11uM - 10uM	24H