Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMD6AJO)

Drug Name
N6-CYCLOPENTYLADENOSINE Drug Info
Synonyms
N6-Cyclopentyladenosine; 41552-82-3; n-cyclopentyladenosine; (2R,3R,4S,5R)-2-(6-(Cyclopentylamino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol; Cyclopentyladenosine; CHEMBL68738; MLS000028368; N(6)-Cyclopentyladenosine; SMR000058639; (2R,3R,4S,5R)-2-[6-(cyclopentylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol; Adenosine, N-cyclopentyl-; UNII-7LG47VG1ID; 7LG47VG1ID; N6-CyclopentylAdo; n-cyclopentyl-adenosine; n6-cyclopentyl-adenosine; AC1LCWG1; Opera_ID_1056; GTPL380; MLS002153196; MLS001077332; SCHEMBL120481
Cross-matching ID
PubChem CID
657378
ChEBI ID
CHEMBL68738
CAS Number
CAS 41552-82-3
TTD Drug ID
D03RFA
VARIDT Drug ID
DR00860

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
TNF signaling pathway 2.07 0.00e+0 103/112 (91.96%) CXCL10;CXCL5;BIRC3;...
Viral protein interaction with cytokine and cytokine re... 1.99 0.00e+0 84/100 (84%) CXCL14;ACKR3;CXCL10;...
Other types of O-glycan biosynthesis 1.99 0.00e+0 29/47 (61.7%) OGT;GALNT14;GALNT10;...
Mucin type O-glycan biosynthesis 1.91 4.27e-3 20/36 (55.56%) GALNT14;GALNT10;GALNT12;...
Homologous recombination 1.89 6.84e-3 35/41 (85.37%) NBN;RAD50;SSBP1;...
IL-17 signaling pathway 1.74 4.84e-2 84/94 (89.36%) CXCL10;CXCL5;FOSB;...
Steroid biosynthesis -2.13 1.14e-2 19/20 (95%) HSD17B7;TM7SF2;LSS;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H