General Information of Drug (ID: DMD7L48)

Drug Name
Plinabulin Drug Info
Synonyms NPI-2358
Cross-matching ID
PubChem CID
9949641
ChEBI ID
CHEMBL1096380
CAS Number
CAS 714272-27-2
TTD Drug ID
D0ZE1O

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Focal adhesion 2.22 1.15e-2 180/201 (89.55%) ACTN4;ACTN1;LAMC2;...
ECM-receptor interaction 2.18 5.76e-3 80/88 (90.91%) LAMC2;COL9A3;ITGA5;...
Dilated cardiomyopathy 2.01 3.84e-3 86/96 (89.58%) ITGA5;TNNC1;ADCY9;...
TNF signaling pathway 1.99 5.76e-3 103/112 (91.96%) CXCL3;PIK3CD;CXCL2;...
Proteoglycans in cancer 1.97 4.60e-3 172/205 (83.9%) PLAUR;PIK3CD;CCND1;...
Mineral absorption 1.96 5.76e-3 48/60 (80%) MT1M;MT1F;MT1E;...
Estrogen signaling pathway 1.94 6.58e-3 119/137 (86.86%) CALML5;PIK3CD;ITPR3;...
Arrhythmogenic right ventricular cardiomyopathy 1.92 5.76e-3 70/77 (90.91%) ITGA5;ITGA6;DSP;...
Regulation of lipolysis in adipocytes 1.92 8.95e-3 52/55 (94.55%) MGLL;PIK3CD;ADCY9;...
VEGF signaling pathway 1.89 9.21e-3 50/59 (84.75%) PIK3CD;SPHK1;MAPK13;...
AMPK signaling pathway 1.87 1.15e-2 106/120 (88.33%) PFKP;PIK3CD;CCND1;...
Shigellosis 1.86 1.06e-2 180/246 (73.17%) ACTN4;ACTN1;PIK3CD;...
Regulation of actin cytoskeleton 1.86 9.74e-3 185/218 (84.86%) ACTN4;ACTN1;MYH9;...
MicroRNAs in cancer 1.84 1.23e-2 146/310 (47.1%) SLC7A1;PIK3CD;CCND1;...
Gastric acid secretion 1.83 1.15e-2 63/76 (82.89%) CALML5;ITPR3;ADCY9;...
Apelin signaling pathway 1.81 1.22e-2 117/137 (85.4%) SERPINE1;CALML5;CCND1;...
IL-17 signaling pathway 1.81 1.15e-2 84/94 (89.36%) FOSL1;CXCL3;CXCL2;...
Apoptosis 1.80 1.21e-2 126/168 (75%) CTSB;PIK3CD;BID;...
C-type lectin receptor signaling pathway 1.78 1.20e-2 93/104 (89.42%) CALML5;PIK3CD;ITPR3;...
Osteoclast differentiation 1.78 1.15e-2 117/127 (92.13%) FOSL1;PIK3CD;RELB;...
AGE-RAGE signaling pathway in diabetic complications 1.78 1.11e-2 97/100 (97%) F3;SERPINE1;PIK3CD;...
Phosphatidylinositol signaling system 1.78 1.07e-2 82/97 (84.54%) CALML5;PIK3CD;ITPR3;...
Sphingolipid signaling pathway 1.78 1.15e-2 106/119 (89.08%) PIK3CD;BID;GAB2;...
Notch signaling pathway 1.77 1.19e-2 49/59 (83.05%) DVL1;TLE1;NCOR2;...
ErbB signaling pathway 1.75 1.22e-2 79/85 (92.94%) PIK3CD;TGFA;HBEGF;...
Pathogenic Escherichia coli infection 1.75 1.18e-2 152/197 (77.16%) MYH9;IRAK1;EZR;...
GnRH secretion 1.75 1.15e-2 60/64 (93.75%) PIK3CD;ITPR3;AKT3;...
Amoebiasis 1.74 1.18e-2 99/102 (97.06%) ACTN4;ACTN1;LAMC2;...
Inflammatory mediator regulation of TRP channels 1.72 1.24e-2 82/98 (83.67%) CALML5;PIK3CD;ITPR3;...
Rap1 signaling pathway 1.72 1.24e-2 184/210 (87.62%) CALML5;PIK3CD;ADCY9;...
Folate biosynthesis -1.67 4.93e-2 23/26 (88.46%) AKR1B10;AKR1C3
Glutathione metabolism -1.69 4.45e-2 43/57 (75.44%) RRM2;PGD;HPGDS;...
Mismatch repair -1.75 2.91e-2 22/23 (95.65%) LIG1;RPA2;MLH1;...
Nucleotide excision repair -1.83 1.37e-2 40/47 (85.11%) POLD1;GTF2H3;RBX1;...
Metabolism of xenobiotics by cytochrome P450 -2.08 1.90e-3 49/77 (63.64%) CYP2C9;UGT2B15;GSTM3;...
Steroid hormone biosynthesis -2.17 0.00e+0 43/61 (70.49%) COMT;DHRS11;HSD11B2;...
Oxidative phosphorylation -2.30 0.00e+0 93/133 (69.92%) ATP5MC3;NDUFC1;ATP6V0C;...
Ribosome -2.32 0.00e+0 113/158 (71.52%) MRPL33;RPL27A;MRPS11;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H