General Information of Drug (ID: DMD9WSC)

Drug Name
Memantine Drug Info
Synonyms Memantine ER; Namenda XR; Memantine (extended release); Memantine (extended release), Forest
Cross-matching ID
PubChem CID
4054
ChEBI ID
CHEMBL807
CAS Number
CAS 19982-08-2
TTD Drug ID
D01JEU
VARIDT Drug ID
DR00023
INTEDE Drug ID
DR2292
ACDINA Drug ID
D00395

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Propanoate metabolism 2.07 0.00e+0 30/34 (88.24%) DLD;ALDH6A1;SUCLG2;...
Valine, leucine and isoleucine degradation 1.89 2.31e-2 42/48 (87.5%) DLD;ALDH2;ALDH6A1;...
Nitrogen metabolism 1.84 3.07e-2 16/17 (94.12%) CPS1;CA4;CA2;...
Fatty acid degradation 1.81 3.00e-2 40/43 (93.02%) ALDH2;ALDH3A2;ACAT1;...
Histidine metabolism 1.79 3.32e-2 16/22 (72.73%) ALDH2;ALDH3A2;ALDH3A1;...
Proximal tubule bicarbonate reclamation 1.79 2.77e-2 21/23 (91.3%) SLC4A4;ATP1B3;CA4;...
DNA replication 1.76 2.90e-2 34/36 (94.44%) RFC2;RFC5;MCM4;...
Thyroid cancer 1.72 4.04e-2 36/37 (97.3%) KRAS;GADD45B;NCOA4;...
Toll-like receptor signaling pathway -1.61 4.25e-2 94/104 (90.38%) TAB2;MAPK1;IFNA16;...
Cytokine-cytokine receptor interaction -1.62 4.21e-2 246/295 (83.39%) TNFRSF11A;CCL4;CSH1;...
Phagosome -1.63 4.05e-2 118/152 (77.63%) CLEC4M;TCIRG1;MARCO;...
Hepatitis B -1.63 4.12e-2 151/162 (93.21%) TAB2;MAPK1;IFNA16;...
Nicotinate and nicotinamide metabolism -1.64 4.08e-2 25/35 (71.43%) NT5E;PNP;AOX1;...
Shigellosis -1.67 3.34e-2 180/246 (73.17%) NAIP;PIK3R2;PFN2;...
Proteasome -1.67 3.48e-2 44/46 (95.65%) PSMB3;PSMB1;PSMA1;...
Salmonella infection -1.67 3.54e-2 198/249 (79.52%) NAIP;PFN2;CASP8;...
Yersinia infection -1.67 3.65e-2 120/137 (87.59%) PIK3R2;ARPC5;PIP5K1C;...
Lysosome -1.68 3.72e-2 115/128 (89.84%) ARSB;CTSD;SLC11A1;...
Lipid and atherosclerosis -1.69 3.32e-2 190/215 (88.37%) TAB2;TANK;MAPK1;...
Prion disease -1.70 3.33e-2 209/273 (76.56%) MAPK1;NDUFB11;CAV2;...
Leishmaniasis -1.73 2.74e-2 67/77 (87.01%) ITGA4;CYBB;MYD88;...
Osteoclast differentiation -1.76 1.89e-2 117/127 (92.13%) TAB2;SOCS3;MAPK1;...
Staphylococcus aureus infection -1.78 1.87e-2 72/95 (75.79%) FCGR3B;KRT18;C5AR1;...
Complement and coagulation cascades -1.78 1.86e-2 76/85 (89.41%) C1QB;CFH;C8G;...
Neutrophil extracellular trap formation -1.79 1.91e-2 101/189 (53.44%) CLCN5;TLR4;AQP9;...
TNF signaling pathway -1.80 1.73e-2 103/112 (91.96%) TAB2;SOCS3;MAPK1;...
Pertussis -1.81 1.61e-2 64/76 (84.21%) C1QA;IL23A;TRAF6;...
Measles -1.82 1.75e-2 133/139 (95.68%) PIK3R2;CASP8;CDK4;...
Tuberculosis -1.82 1.93e-2 159/180 (88.33%) TLR6;CD209;ATP6V0A2;...
RIG-I-like receptor signaling pathway -1.83 1.78e-2 64/70 (91.43%) TANK;IFNA16;AZI2;...
Rheumatoid arthritis -1.85 1.34e-2 78/93 (83.87%) TNFRSF11A;ATP6V1G1;FLT1;...
Transcriptional misregulation in cancer -1.89 6.12e-3 158/192 (82.29%) FUT8;TAF15;NGFR;...
IL-17 signaling pathway -1.91 5.35e-3 84/94 (89.36%) FADD;MMP13;TRAF5;...
Viral protein interaction with cytokine and cytokine re... -1.99 4.28e-3 84/100 (84%) IL18RAP;CXCL11;CSF1;...
Coronavirus disease -1.99 5.35e-3 215/232 (92.67%) RPL7;C1QA;PIK3R2;...
NOD-like receptor signaling pathway -2.02 0.00e+0 145/181 (80.11%) TLR4;VDAC1;TXN;...
Malaria -2.03 0.00e+0 44/50 (88%) GYPB;SELE;MYD88;...
Legionellosis -2.03 0.00e+0 51/57 (89.47%) MYD88;IL1B;SAR1B;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 20uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H