Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMDBX5F)

Drug Name
Ivermectin Drug Info
Synonyms I 8898; Ivexterm (TN); MK-933; Mectizan (TN); Stromectol (TN)
Therapeutic ClassAntiprotozoal Agents
Cross-matching ID
PubChem CID
6321424
ChEBI ID
CHEMBL63941
CAS Number
CAS 71827-03-7
TTD Drug ID
D09YHJ
VARIDT Drug ID
DR00147
INTEDE Drug ID
DR0899
ACDINA Drug ID
D00340

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cysteine and methionine metabolism 2.09 1.70e-2 43/50 (86%) CBS;PSAT1;CTH;...
Protein export 1.94 2.13e-2 17/23 (73.91%) OXA1L;SEC63;SRP72;...
Glycine, serine and threonine metabolism 1.80 3.98e-2 31/40 (77.5%) CBS;PSAT1;CTH;...
Viral protein interaction with cytokine and cytokine re... -1.67 3.39e-2 84/100 (84%) IL22RA1;CXCL6;IL6ST;...
Fatty acid biosynthesis -1.68 3.24e-2 16/18 (88.89%) ACSL3;ACSBG1;ACSL1;...
Viral myocarditis -1.68 3.38e-2 53/60 (88.33%) RAC1;HLA-F;EIF4G2;...
Prion disease -1.70 2.80e-2 209/273 (76.56%) PSMC2;PSMD13;PSMA5;...
Type I diabetes mellitus -1.71 2.84e-2 38/43 (88.37%) HLA-G;GAD1;HLA-DOB;...
Autoimmune thyroid disease -1.80 1.15e-2 46/53 (86.79%) HLA-F;TPO;HLA-B;...
Parkinson disease -1.81 1.26e-2 176/249 (70.68%) SLC18A2;PSMC2;PSMD13;...
DNA replication -1.82 1.04e-2 34/36 (94.44%) POLD3;RNASEH2A;RPA1;...
Antigen processing and presentation -1.83 7.69e-3 60/78 (76.92%) TAP2;KIR2DL4;PSME3;...
Cell cycle -1.84 7.21e-3 110/124 (88.71%) CDKN1C;RBL2;CCNB1;...
Asthma -1.87 6.59e-3 25/31 (80.65%) RNASE3;FCER1A;IL13;...
Legionellosis -1.90 5.77e-3 51/57 (89.47%) CASP7;IL6;HSPA6;...
Spliceosome -1.94 2.31e-3 101/150 (67.33%) DDX5;SRSF5;SNRNP40;...
Allograft rejection -1.96 2.88e-3 32/38 (84.21%) HLA-F;HLA-B;HLA-G;...
Proteasome -1.98 3.85e-3 44/46 (95.65%) PSMA1;PSMD7;SEM1;...
Steroid biosynthesis -2.06 0.00e+0 19/20 (95%) LBR;CYP51A1;HSD17B7;...
Progesterone-mediated oocyte maturation -2.08 0.00e+0 75/100 (75%) CCNB1;CDK1;PIK3CD;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 3.33uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 3.33uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 3.33uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 3.33uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 3.33uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 3.33uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 3.33uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 3.33uM 24H