Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMDE8YS)

Drug Name
TW-37 Drug Info
Synonyms
TW-37; 877877-35-5; N-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide; tw 37; CHEMBL217354; N-(4-((2-(tert-butyl)phenyl)sulfonyl)phenyl)-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide; N-(4-(2-tert-butylphenylsulfonyl)phenyl)-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide; N-[4-[(2-tert-Butylphenyl)sulfonyl]phenyl]-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide; N-(4-((2-Tert-Butylphenyl)sulfonyl)phenyl)-2,3,4-trihydroxy-5-((2-isopropylphenyl)methyl)benzamide
Cross-matching ID
PubChem CID
11455910
ChEBI ID
CHEMBL217354
CAS Number
CAS 877877-35-5
TTD Drug ID
D00LHS

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
HIF-1 signaling pathway 2.51 0.00e+0 105/109 (96.33%) ENO2;ALDOC;HK2;...
Fructose and mannose metabolism 2.50 0.00e+0 30/33 (90.91%) ALDOC;HK2;PFKP;...
Glycolysis / Gluconeogenesis 2.39 0.00e+0 56/67 (83.58%) ENO2;ALDOC;HK2;...
Amino sugar and nucleotide sugar metabolism 2.34 0.00e+0 38/48 (79.17%) HK2;GPI;PGM1;...
Galactose metabolism 2.23 0.00e+0 26/31 (83.87%) HK2;PFKP;PGM1;...
Central carbon metabolism in cancer 2.17 0.00e+0 67/70 (95.71%) HK2;SLC2A1;PFKP;...
Mitophagy 2.14 0.00e+0 56/68 (82.35%) BNIP3;BNIP3L;ATF4;...
Pentose phosphate pathway 2.13 0.00e+0 25/30 (83.33%) ALDOC;PFKP;GPI;...
Starch and sucrose metabolism 2.11 0.00e+0 25/36 (69.44%) HK2;GBE1;GPI;...
Glycine, serine and threonine metabolism 2.08 0.00e+0 31/40 (77.5%) PHGDH;SHMT2;CBS;...
TNF signaling pathway 2.07 0.00e+0 103/112 (91.96%) ATF4;PTGS2;NFKBIA;...
Ferroptosis 2.00 1.99e-3 36/41 (87.8%) SLC39A14;SLC7A11;TFRC;...
Renal cell carcinoma 1.96 3.67e-3 68/69 (98.55%) SLC2A1;VEGFA;EGLN3;...
Glucagon signaling pathway 1.93 4.26e-3 89/107 (83.18%) SLC2A1;PFKP;PCK2;...
Bladder cancer 1.93 3.97e-3 40/41 (97.56%) VEGFA;CXCL8;CDKN1A;...
Circadian rhythm 1.87 9.69e-3 26/31 (83.87%) BHLHE40;BHLHE41;RORA;...
MicroRNAs in cancer 1.85 1.47e-2 146/310 (47.1%) DDIT4;VEGFA;CDKN1A;...
IL-17 signaling pathway 1.82 1.79e-2 84/94 (89.36%) CXCL8;PTGS2;NFKBIA;...
Shigellosis 1.80 1.88e-2 180/246 (73.17%) BNIP3;HK2;CXCL8;...
p53 signaling pathway 1.79 1.79e-2 63/73 (86.3%) IGFBP3;CDKN1A;DDB2;...
Insulin resistance 1.75 2.67e-2 96/108 (88.89%) SLC2A1;PPP1R3C;PCK2;...
Fluid shear stress and atherosclerosis 1.74 2.98e-2 123/139 (88.49%) VEGFA;PDGFA;ASS1;...
One carbon pool by folate 1.72 3.89e-2 15/20 (75%) SHMT2;MTHFD2;TYMS;...
RNA degradation 1.72 3.73e-2 53/79 (67.09%) ENO2;PFKP;PFKL;...
Protein processing in endoplasmic reticulum 1.72 3.62e-2 127/171 (74.27%) ERO1A;DDIT3;DNAJB2;...
Prostate cancer 1.71 3.58e-2 93/97 (95.88%) CDKN1A;PDGFA;ATF4;...
Neomycin, kanamycin and gentamicin biosynthesis 1.69 3.93e-2 5/5 (100%) HK2;HK1
Primary immunodeficiency -1.64 4.65e-2 33/38 (86.84%) RAG1;IKBKG;CD8B;...
Basal transcription factors -1.66 4.24e-2 37/45 (82.22%) TBP;TAF4B;TAF6L;...
Terpenoid backbone biosynthesis -1.68 4.27e-2 18/22 (81.82%) FDPS;HMGCR;DHDDS;...
Aminoacyl-tRNA biosynthesis -1.78 1.22e-2 15/66 (22.73%) GATC;SARS2;FARSA;...
RNA transport -1.79 1.20e-2 128/186 (68.82%) NUP37;RANBP2;AAAS;...
Systemic lupus erythematosus -1.94 1.66e-3 45/135 (33.33%) FCGR2A;C8G;IFNG;...
Ribosome biogenesis in eukaryotes -2.06 0.00e+0 52/108 (48.15%) IMP4;HEATR1;REXO2;...
Proteasome -2.33 0.00e+0 44/46 (95.65%) PSME1;PSMC6;PSMD7;...
Spliceosome -2.39 0.00e+0 101/150 (67.33%) HNRNPK;SRSF6;SF3A2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
SK-ES-1 CVCL_0627 Homo sapiens 0.08uM - 10uM 24H
TC-32 CVCL_7141 Homo sapiens 0.08uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.08uM - 10uM 6H, 24H, 48H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 0.08uM - 10uM 24H
YH-13 CVCL_1800 Homo sapiens 0.08uM - 10uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 0.08uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H, 48H
MDA-MB-468 CVCL_0419 Homo sapiens 0.08uM - 0.74uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.08uM - 10uM 24H
T-47D CVCL_0553 Homo sapiens 0.08uM - 0.74uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.08uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
GP2d CVCL_1234 Homo sapiens 0.08uM - 10uM 24H
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-407 CVCL_5004 Homo sapiens 0.08uM - 10uM 24H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.08uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.08uM - 10uM 6H, 24H
HEC-151 CVCL_2927 Homo sapiens 0.08uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.08uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.08uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 0.74uM 24H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 0.08uM - 0.74uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 0.08uM - 10uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.08uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 0.08uM - 0.74uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.08uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H, 48H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
NCI-H1437 CVCL_1472 Homo sapiens 0.08uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 0.08uM - 0.74uM 24H
NCI-H838 CVCL_1594 Homo sapiens 0.08uM - 10uM 24H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 0.08uM - 0.74uM 24H
HCC15 CVCL_1253 Homo sapiens 10uM 6H
HCC1588 CVCL_1263 Homo sapiens 0.08uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 0.08uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
NCI-H2110 CVCL_1529 Homo sapiens 0.08uM - 10uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.08uM - 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
NCI-H841 CVCL_1595 Homo sapiens 0.08uM - 10uM 24H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 0.08uM - 0.74uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 0.08uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
OVK18 CVCL_1629 Homo sapiens 0.08uM - 10uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.08uM - 10uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.08uM - 10uM 24H
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 0.08uM - 10uM 24H
OC 316 CVCL_1615 Homo sapiens 0.08uM - 10uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 0.08uM - 0.74uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.08uM - 10uM 24H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.08uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 10uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.08uM - 10uM 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.08uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 0.08uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 0.08uM - 0.74uM 24H
SH-4 CVCL_1692 Homo sapiens 0.08uM - 0.74uM 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
SK-MEL-3 CVCL_0525 Homo sapiens 0.08uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.08uM - 10uM 6H, 24H
MKN45 CVCL_0434 Homo sapiens 0.08uM - 10uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.08uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 0.08uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 0.08uM - 10uM 24H