Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMDF79Z)

Drug Name
Acetylcholine Drug Info
Synonyms
acetylcholine; Choline acetate; O-Acetylcholine; Acetyl choline ion; Acetylcholinum; 51-84-3; (2-Acetoxyethyl)trimethylammonium; Acetyl choline cation; Choline acetate (ester); 2-(Acetyloxy)-N,N,N-trimethylethanaminium; Ach; Azetylcholin; ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; UNII-N9YNS0M02X; BRN 1764436; CHEBI:15355; Bromoacetylcholine; EINECS 200-128-9; CHEMBL667; N9YNS0M02X; [2-(acetyloxy)ethyl]trimethylazanium; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl- (9CI); 2-acetyloxyethyl-trimethylazanium; [3H]acetylcholine; Miochol; Miochol-e
Therapeutic ClassCardiovascular Agents
Cross-matching ID
PubChem CID
187
ChEBI ID
CHEMBL667
CAS Number
CAS 51-84-3
TTD Drug ID
D0Q9HF
VARIDT Drug ID
DR00070
INTEDE Drug ID
DR0041

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Longevity regulating pathway -1.69 4.71e-2 90/151 (59.6%) TSC1;EIF4E2;ATF4;...
TGF-beta signaling pathway -1.69 4.90e-2 81/94 (86.17%) TGFBR1;SMAD1;ACVR2A;...
Adipocytokine signaling pathway -1.71 4.66e-2 64/69 (92.75%) NPY;CAMKK2;CHUK;...
Porphyrin and chlorophyll metabolism -1.73 4.50e-2 23/43 (53.49%) CPOX;GUSB;UGT2B28;...
Linoleic acid metabolism -1.78 2.36e-2 21/29 (72.41%) CYP2C9;CYP3A4;CYP2E1;...
Mitophagy -1.79 2.50e-2 56/68 (82.35%) RELA;FIS1;CSNK2B;...
Arginine biosynthesis -1.79 2.50e-2 17/22 (77.27%) GLUD2;NOS2;NOS3;...
Rheumatoid arthritis -1.81 2.50e-2 78/93 (83.87%) TEK;TNFRSF11A;ATP6V0B;...
Retinol metabolism -1.89 1.50e-2 41/68 (60.29%) RDH16;UGT2B15;ADH1A;...
Steroid hormone biosynthesis -1.90 1.56e-2 43/61 (70.49%) UGT2B15;AKR1C2;CYP3A5;...
Complement and coagulation cascades -1.96 8.33e-3 76/85 (89.41%) CFHR5;CFI;C8B;...
Metabolism of xenobiotics by cytochrome P450 -1.96 1.25e-2 49/77 (63.64%) GSTA1;UGT2B4;CYP2A13;...
Ferroptosis -2.02 1.25e-2 36/41 (87.8%) ALOX15;ATG7;SLC39A8;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 25uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H