Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMDG8Q3)

Drug Name
Varlitinib Drug Info
Synonyms
VARLITINIB; 845272-21-1; ARRY-334543; ARRY334543; ARRY 334543; ARRY-543; UNII-846Y8197W1; ASLAN-001; 846Y8197W1; (R)-N4-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6-(4-methyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine; Varlitinib [USAN:INN]; Varlitinib (ARRY334543); Varlitinib free base; Varlitinib (USAN/INN); MLS006011274; GTPL7645; SCHEMBL1384578; CHEMBL2103842; SYN1192; MolPort-028-720-424; EX-A1005; 4-N-[3-chloro-4-(1,3-thiazol-2-ylmethoxy)phenyl]-6-N-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]quinazoline-4,6-diamine
Cross-matching ID
PubChem CID
42642648
ChEBI ID
CHEMBL2103842
CAS Number
CAS 845272-21-1
TTD Drug ID
D00NYJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Pyruvate metabolism 2.08 2.13e-2 41/47 (87.23%) ADH1C;ACAT1;PCK1;...
Oxidative phosphorylation 2.03 1.59e-2 93/133 (69.92%) ATP5PD;ATP6V1H;ATP6V1C1;...
Proximal tubule bicarbonate reclamation 2.02 1.06e-2 21/23 (91.3%) CA2;ATP1A2;PCK1;...
Glyoxylate and dicarboxylate metabolism 2.00 1.06e-2 23/30 (76.67%) GLUL;ACAT1;GRHPR;...
Citrate cycle (TCA cycle) 1.98 8.51e-3 30/30 (100%) PCK1;PCK2;DLAT;...
Butanoate metabolism 1.95 7.09e-3 23/28 (82.14%) ALDH5A1;ACAT1;HMGCS2;...
Propanoate metabolism 1.92 6.08e-3 30/34 (88.24%) ACAT1;ALDH6A1;ECHDC1;...
Retinol metabolism 1.89 6.64e-3 41/68 (60.29%) ADH1C;DHRS3;ADH1B;...
Parkinson disease 1.82 1.18e-2 176/249 (70.68%) DAXX;ATP5PD;GNAI1;...
Prion disease 1.81 1.17e-2 209/273 (76.56%) HSPA8;ATP5PD;SLC25A5;...
Glycolysis / Gluconeogenesis 1.81 1.16e-2 56/67 (83.58%) ADH1C;PCK1;PFKL;...
PPAR signaling pathway 1.77 1.95e-2 66/74 (89.19%) FABP4;ACSL5;PCK1;...
Fatty acid degradation 1.76 1.88e-2 40/43 (93.02%) ACSL5;ADH1C;ACAT1;...
Arginine biosynthesis 1.76 1.75e-2 17/22 (77.27%) GLUL;ARG1;GLUD2;...
One carbon pool by folate 1.75 1.70e-2 15/20 (75%) ATIC;MTHFD1;ALDH1L1;...
Diabetic cardiomyopathy 1.74 2.06e-2 162/203 (79.8%) ATP5PD;SLC25A5;PLN;...
Tyrosine metabolism 1.72 2.81e-2 30/36 (83.33%) ADH1C;ADH1B;ADH5;...
Biosynthesis of unsaturated fatty acids 1.72 2.66e-2 21/27 (77.78%) HSD17B4;ELOVL2;ACOT7;...
GABAergic synapse 1.70 3.02e-2 76/89 (85.39%) GLUL;SLC38A2;SRC;...
Thermogenesis 1.69 2.98e-2 173/232 (74.57%) ACSL5;ATP5PD;NDUFB8;...
Amyotrophic lateral sclerosis 1.66 3.80e-2 267/364 (73.35%) DAXX;ATP5PD;PSMA7;...
Terpenoid backbone biosynthesis 1.65 4.06e-2 18/22 (81.82%) ACAT1;IDI1;HMGCS2;...
Non-alcoholic fatty liver disease 1.63 4.48e-2 126/155 (81.29%) IL1A;NDUFB8;NDUFV2;...
RNA degradation 1.63 4.30e-2 53/79 (67.09%) BTG1;PFKL;BTG3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H