Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMDGPY9)

Drug Name
LINOLEIC ACID Drug Info
Synonyms
linoleic acid; 60-33-3; Linolic acid; Telfairic acid; (9Z,12Z)-octadeca-9,12-dienoic acid; cis,cis-Linoleic acid; Grape seed oil; Linoleate; cis,cis-9,12-Octadecadienoic acid; Emersol 315; cis-9,cis-12-Octadecadienoic acid; 9,12-Linoleic acid; Unifac 6550; 9Z,12Z-Linoleic acid; Extra Linoleic 90; 9-cis,12-cis-Linoleic acid; Polylin 515; Emersol 310; Polylin No. 515; Oils, grape; 9Z,12Z-octadecadienoic acid; alpha-Linoleic acid; all-cis-9,12-Octadecadienoic acid; Linoleic; acide linoleique; (Z,Z)-9,12-Octadecadienoic acid; acido lino
Cross-matching ID
PubChem CID
5280450
ChEBI ID
CHEMBL267476
CAS Number
CAS 60-33-3
TTD Drug ID
D03LOG
INTEDE Drug ID
DR2161

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
RNA transport 2.35 0.00e+0 128/186 (68.82%) EIF2S3;NMD3;NUP85;...
Spliceosome 2.30 0.00e+0 101/150 (67.33%) LSM6;PUF60;HSPA8;...
Ribosome biogenesis in eukaryotes 2.24 0.00e+0 52/108 (48.15%) NMD3;FBL;NAT10;...
Protein export 2.00 1.84e-3 17/23 (73.91%) SRP72;OXA1L;SPCS1;...
DNA replication 1.89 2.94e-3 34/36 (94.44%) SSBP1;MCM4;MCM3;...
Cell cycle 1.77 1.72e-2 110/124 (88.71%) CCND1;PLK1;TFDP1;...
Nicotine addiction 1.76 1.79e-2 32/40 (80%) GABRE;GRIA2;GABRA2;...
RNA degradation 1.73 2.21e-2 53/79 (67.09%) LSM6;PABPC4;HSPA9;...
Base excision repair 1.71 2.45e-2 29/33 (87.88%) PARP2;APEX1;POLE3;...
mRNA surveillance pathway 1.70 2.35e-2 71/98 (72.45%) PNN;CPSF6;PABPC4;...
Hedgehog signaling pathway 1.64 3.74e-2 43/56 (76.79%) CCND1;CSNK1A1;CCND2;...
Hippo signaling pathway 1.63 3.68e-2 120/186 (64.52%) ID1;CCND1;AREG;...
Viral protein interaction with cytokine and cytokine re... -1.80 4.39e-2 84/100 (84%) CCR9;CXCL2;CCL18;...
Hematopoietic cell lineage -1.95 1.52e-2 90/99 (90.91%) DNTT;IL3RA;CD22;...
Mitophagy -2.04 8.13e-3 56/68 (82.35%) CSNK2A1;NBR1;RAB7A;...
Primary immunodeficiency -2.10 0.00e+0 33/38 (86.84%) ZAP70;CD79A;RAG1;...
Steroid biosynthesis -2.13 0.00e+0 19/20 (95%) CYP27B1;SOAT1;HSD17B7;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H