Details of the Drug Pharmacogenomic Perturbation Atlas

Megestrol Drug Info

Chronopil; Megestrolo; Megestrolo [DCIT]; Chronopil (TN); Megace (TN); Megestrol (INN); Megestrol [INN:BAN]; Megestrolum [INN-Latin]; (8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one; 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione

Therapeutic Class

Anticancer Agents

Cross-matching ID

PubChem CID

19090

CAS Number

CAS 3562-63-8

TTD Drug ID

D04GJN

INTEDE Drug ID

DR1017

General Information of Drug (ID: DMDH9KX)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid hormone biosynthesis	2.06	0.00e+0	43/61 (70.49%)	AKR1C3;CYP1B1;AKR1C2;...
Ovarian steroidogenesis	2.03	0.00e+0	41/51 (80.39%)	AKR1C3;CYP1B1;CYP1A1;...
Arachidonic acid metabolism	1.90	9.89e-3	48/61 (78.69%)	AKR1C3;GPX2;PLA2G2A;...
Allograft rejection	-1.88	4.04e-2	32/38 (84.21%)	FASLG;CD80;GZMB;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H

Prostate

Prostate carcinoma

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H