Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMDHYM7)

Drug Name
Torcetrapib Drug Info
Synonyms
Torcetrapib [USAN]; CP 529414; CP-529414; CP-529,414; Torcetrapib (USAN/INN); Ethyl (2R,4S)-4-[[3,5-bis(trifluoromethyl)phenyl]methyl-methoxycarbonylamino]-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-2H-quinoline-1-carboxylate; Ethyl (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl](methoxycarbonyl)amino}-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate; Ethyl (2R,4S)-4-((3,5-bis(trifluoromethyl)benzyl)(methoxycarbonyl)amino)-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate; (2R,4S)-4-((3,5-Bis-trifluoromethylbenzyl)methoxycarbonylamino)-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester
Cross-matching ID
PubChem CID
159325
ChEBI ID
CHEMBL479527
CAS Number
CAS 262352-17-0
TTD Drug ID
D07GDN
INTEDE Drug ID
DR1786

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cholinergic synapse 1.91 1.35e-2 99/113 (87.61%) PRKACB;AKT3;GNG11;...
GnRH secretion 1.89 1.35e-2 60/64 (93.75%) SPP1;AKT3;PRKCA;...
Circadian entrainment 1.88 1.80e-2 85/97 (87.63%) PRKACB;GNAS;GRIA2;...
Cortisol synthesis and secretion 1.88 2.02e-2 58/65 (89.23%) PRKACB;GNAS;PBX1;...
Insulin secretion 1.88 1.62e-2 75/86 (87.21%) PRKACB;GNAS;PRKCA;...
Morphine addiction 1.88 1.35e-2 80/91 (87.91%) PRKACB;GNAS;GNG11;...
GABAergic synapse 1.85 1.73e-2 76/89 (85.39%) PRKACB;SRC;GNG11;...
Citrate cycle (TCA cycle) 1.82 2.19e-2 30/30 (100%) ACLY;IDH2;ACO2;...
Glutamatergic synapse 1.81 2.70e-2 97/114 (85.09%) PRKACB;GNAS;GRIA2;...
Mucin type O-glycan biosynthesis 1.77 3.37e-2 20/36 (55.56%) ST6GALNAC2;GALNT7;GALNT3;...
Pyrimidine metabolism 1.75 3.68e-2 40/56 (71.43%) TK1;NME1;ENTPD6;...
Glucagon signaling pathway 1.75 3.37e-2 89/107 (83.18%) PRKACB;GNAS;AKT3;...
Relaxin signaling pathway 1.73 3.63e-2 114/129 (88.37%) PRKACB;SRC;VEGFA;...
Gap junction 1.72 3.56e-2 72/88 (81.82%) PRKACB;SRC;GNAS;...
Endocrine and other factor-regulated calcium reabsorpti... 1.70 4.94e-2 49/53 (92.45%) PRKACB;GNAS;PRKCA;...
Mineral absorption -1.86 2.19e-2 48/60 (80%) ATP1A1;SLC31A1;ATP2B2;...
Malaria -1.90 1.46e-2 44/50 (88%) ITGAL;IL18;COMP;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H