Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMDINFS)

• Drug Name: Sanguinarine Drug Info
• Synonyms: SANGUINARINE; 2447-54-3; Pseudochelerythrine; Sanguinarin; sangvinarin; Veadent; Sanguiritrin; SANGUINARIUM; Dimethylenedioxy benzphenanthridine; UNII-AV9VK043SS; C20H14NO4; EINECS 219-503-3; Benzophenanthridine alkaloid; BRN 3915507; AV9VK043SS; CHEBI:17183; NCGC00015959-03; CAS-2447-54-3; [1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium, 13-methyl-; DSSTox_RID_80748; DSSTox_CID_25204; DSSTox_GSID_45204; 13-Methyl[1,3]benzodioxolo[5,6-C][1,3]dioxolo[4,5-I]phenanthridin-13-Ium; Sangrovit; y-Chelerythrine; SR-01000075650
• Cross-matching ID:
  PubChem CID: 5154
  ChEBI ID: CHEMBL417799
  CAS Number: CAS 2447-54-3
  TTD Drug ID: D0T3NB
  VARIDT Drug ID: DR00919

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Complement and coagulation cascades	2.20	0.00e+0	76/85 (89.41%)	SERPINA1;C3;F3;...
NF-kappa B signaling pathway	2.01	0.00e+0	90/104 (86.54%)	BCL2A1;SYK;CXCL8;...
Steroid biosynthesis	-1.99	1.11e-2	19/20 (95%)	DHCR7;LSS;SQLE;...
Cell cycle	-1.99	2.23e-2	110/124 (88.71%)	SMC3;BUB1B;CDC25C;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	6.66uM	6H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 3.33uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Show ▼