Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMDIYFZ)

Drug Name
Telotristat ethyl Drug Info
Synonyms
Telotristat; Telotristat etiprate; LP-778902; LX-1032; LX-1606; Serotonin modulator (oral, GI disorder/hypertension/carcinoid syndrome), Lexicon; Tryptophan hydroxylase inhibitor (oral, GI disorder/hypertension/carcinoid syndrome), Lexicon
Cross-matching ID
PubChem CID
25181577
ChEBI ID
CHEMBL2105695
CAS Number
CAS 1033805-22-9
TTD Drug ID
D0RE6T
ACDINA Drug ID
D00658

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
IL-17 signaling pathway 2.28 0.00e+0 84/94 (89.36%) CXCL2;CXCL1;CXCL3;...
Chemokine signaling pathway 2.15 0.00e+0 163/192 (84.9%) CXCL2;SRC;CXCL1;...
Viral protein interaction with cytokine and cytokine re... 2.13 0.00e+0 84/100 (84%) CXCL2;CXCL1;CXCL3;...
TNF signaling pathway 2.06 0.00e+0 103/112 (91.96%) CXCL2;CXCL1;CXCL3;...
Staphylococcus aureus infection 2.05 0.00e+0 72/95 (75.79%) CFD;KRT17;DEFA4;...
African trypanosomiasis 2.05 0.00e+0 32/37 (86.49%) IL6;HBB;ICAM1;...
Rheumatoid arthritis 1.98 0.00e+0 78/93 (83.87%) CXCL2;CXCL1;CXCL3;...
Mineral absorption 1.96 0.00e+0 48/60 (80%) MT1F;MT1HL1;MT1G;...
Kaposi sarcoma-associated herpesvirus infection 1.93 1.60e-3 172/193 (89.12%) CXCL2;SRC;CXCL1;...
Amoebiasis 1.92 7.18e-3 99/102 (97.06%) CXCL2;CXCL1;CXCL3;...
NF-kappa B signaling pathway 1.91 6.53e-3 90/104 (86.54%) CXCL2;CXCL1;CXCL3;...
Natural killer cell mediated cytotoxicity 1.88 9.57e-3 99/131 (75.57%) BID;CASP3;KRAS;...
Lipid and atherosclerosis 1.84 1.10e-2 190/215 (88.37%) CXCL2;SRC;CXCL1;...
DNA replication 1.83 1.23e-2 34/36 (94.44%) RFC5;MCM2;PRIM1;...
Neutrophil extracellular trap formation 1.81 1.44e-2 101/189 (53.44%) SRC;CYBA;ELANE;...
Human cytomegalovirus infection 1.79 1.71e-2 201/225 (89.33%) SRC;CXCL8;BID;...
Legionellosis 1.78 1.86e-2 51/57 (89.47%) CXCL2;CXCL1;CXCL3;...
Non-alcoholic fatty liver disease 1.76 2.31e-2 126/155 (81.29%) CXCL8;BID;CASP3;...
AGE-RAGE signaling pathway in diabetic complications 1.75 2.19e-2 97/100 (97%) CXCL8;CASP3;IL6;...
Starch and sucrose metabolism 1.73 2.66e-2 25/36 (69.44%) GPI;MGAM;GYG2;...
Pertussis 1.73 2.53e-2 64/76 (84.21%) CXCL8;CXCL5;CASP3;...
Coronavirus disease 1.67 4.18e-2 215/232 (92.67%) CXCL8;MMP1;CFD;...
Glyoxylate and dicarboxylate metabolism 1.66 4.12e-2 23/30 (76.67%) ACAT2;GLUL;GLDC;...
VEGF signaling pathway 1.65 4.37e-2 50/59 (84.75%) SRC;KRAS;HSPB1;...
Herpes simplex virus 1 infection 1.65 4.71e-2 165/498 (33.13%) SRC;BID;CASP3;...
C-type lectin receptor signaling pathway 1.64 4.70e-2 93/104 (89.42%) SRC;IL6;KRAS;...
Epithelial cell signaling in Helicobacter pylori infect... 1.64 4.68e-2 62/70 (88.57%) CXCL2;SRC;CXCL1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H