Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMDKF3M)

Drug Name
Raloxifene Drug Info
Synonyms Raloxifene (extended-release, CDT)
Cross-matching ID
PubChem CID
5035
ChEBI ID
CHEMBL81
CAS Number
CAS 84449-90-1
TTD Drug ID
D01XBA
VARIDT Drug ID
DR01347
INTEDE Drug ID
DR1388
ACDINA Drug ID
D00579

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.53 0.00e+0 19/20 (95%) MSMO1;SQLE;DHCR7;...
Terpenoid backbone biosynthesis 2.31 0.00e+0 18/22 (81.82%) HMGCS1;ACAT2;IDI1;...
Phagosome 2.18 0.00e+0 118/152 (77.63%) CD36;ATP6V1D;ATP6V0D1;...
Vibrio cholerae infection 2.17 0.00e+0 44/50 (88%) TJP2;ATP6V1D;ATP6V0D1;...
Biosynthesis of unsaturated fatty acids 2.13 0.00e+0 21/27 (77.78%) SCD;FADS1;FADS2;...
PPAR signaling pathway 2.13 0.00e+0 66/74 (89.19%) HMGCS1;SCD;FADS2;...
Lysosome 2.10 0.00e+0 115/128 (89.84%) NPC2;NEU1;LIPA;...
Glycolysis / Gluconeogenesis 2.05 1.35e-3 56/67 (83.58%) ALDOC;ENO2;PKM;...
Pentose phosphate pathway 2.04 1.20e-3 25/30 (83.33%) PGD;ALDOC;G6PD;...
Valine, leucine and isoleucine degradation 1.99 2.16e-3 42/48 (87.5%) HMGCS1;ACAT2;ALDH2;...
Tryptophan metabolism 1.98 1.97e-3 35/42 (83.33%) ACAT2;KYNU;KMO;...
Synaptic vesicle cycle 1.96 2.70e-3 63/78 (80.77%) ATP6V1D;ATP6V0D1;ATP6V0E1;...
Steroid hormone biosynthesis 1.93 4.16e-3 43/61 (70.49%) HSD17B7;AKR1C2;HSD11B1;...
Amino sugar and nucleotide sugar metabolism 1.91 3.86e-3 38/48 (79.17%) GNPDA1;NAGK;AMDHD2;...
Peroxisome 1.90 3.61e-3 72/82 (87.8%) IDH1;ACSL1;ACSL3;...
Primary bile acid biosynthesis 1.90 3.38e-3 15/17 (88.24%) HSD17B4;ACOX2;AMACR;...
Cholesterol metabolism 1.87 5.09e-3 44/50 (88%) LDLR;LIPG;NPC2;...
Fatty acid biosynthesis 1.85 7.21e-3 16/18 (88.89%) FASN;ACSL1;ACACA;...
Synthesis and degradation of ketone bodies 1.85 6.83e-3 9/10 (90%) HMGCS1;ACAT2;BDH1
Glutathione metabolism 1.82 1.14e-2 43/57 (75.44%) PGD;IDH1;G6PD;...
Metabolism of xenobiotics by cytochrome P450 1.82 1.08e-2 49/77 (63.64%) GSTA4;HSD11B1;MGST3;...
Tuberculosis 1.77 2.21e-2 159/180 (88.33%) SRC;FCER1G;ATP6V0D1;...
Fructose and mannose metabolism 1.76 2.45e-2 30/33 (90.91%) ALDOC;AKR1B10;FBP1;...
Ubiquinone and other terpenoid-quinone biosynthesis 1.75 2.48e-2 9/11 (81.82%) NQO1;COQ2;COQ7;...
Fatty acid degradation 1.75 2.47e-2 40/43 (93.02%) ACAT2;ACSL1;ACSL3;...
Collecting duct acid secretion 1.74 2.37e-2 22/27 (81.48%) ATP6V1D;ATP6V0D1;ATP6V0E1;...
Butanoate metabolism 1.71 3.32e-2 23/28 (82.14%) HMGCS1;ACAT2;AACS;...
Rheumatoid arthritis 1.71 3.36e-2 78/93 (83.87%) ATP6V1D;ATP6V0D1;ATP6V0E1;...
Ferroptosis 1.67 4.09e-2 36/41 (87.8%) ACSL1;ACSL3;HMOX1;...
Glycerolipid metabolism 1.67 3.97e-2 44/61 (72.13%) LIPG;AKR1B10;LPIN1;...
Small cell lung cancer -1.77 4.22e-2 90/92 (97.83%) PTEN;TRAF3;TRAF5;...
Melanoma -1.81 4.74e-2 68/72 (94.44%) FGF20;FGF9;PDGFC;...
p53 signaling pathway -1.86 2.67e-2 63/73 (86.3%) CCND2;PIDD1;STEAP3;...
Ribosome biogenesis in eukaryotes -2.10 0.00e+0 52/108 (48.15%) NHP2;NXF3;HEATR1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 0.12uM - 10uM 24H
TC-32 CVCL_7141 Homo sapiens 0.12uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 0.12uM - 10uM 24H
YH-13 CVCL_1800 Homo sapiens 0.12uM - 10uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 0.12uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 0.12uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.12uM - 10uM 24H
T-47D CVCL_0553 Homo sapiens 0.12uM - 10uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.12uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GP2d CVCL_1234 Homo sapiens 0.12uM - 10uM 24H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 0.12uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.12uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.12uM - 10uM 24H
HEC-151 CVCL_2927 Homo sapiens 0.12uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.12uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.12uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 0.12uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 0.12uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 0.12uM - 10uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.12uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 6.66uM 72H
JHH-5 CVCL_1320 Homo sapiens 0.12uM - 10uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.12uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
NCI-H1437 CVCL_1472 Homo sapiens 0.12uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 0.12uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 0.12uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 0.12uM - 10uM 24H
HCC1588 CVCL_1263 Homo sapiens 0.12uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 0.12uM - 10uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.12uM - 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H841 CVCL_1595 Homo sapiens 0.12uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 0.12uM - 10uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 0.12uM - 10uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVK18 CVCL_1629 Homo sapiens 0.12uM - 10uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.12uM - 10uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.12uM - 10uM 24H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 0.12uM - 10uM 24H
OC 316 CVCL_1615 Homo sapiens 0.12uM - 10uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 0.12uM - 10uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.12uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.12uM - 10uM 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.12uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 0.12uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 0.12uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 0.12uM - 10uM 24H
SK-MEL-3 CVCL_0525 Homo sapiens 0.12uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.12uM - 10uM 24H
MKN45 CVCL_0434 Homo sapiens 0.12uM - 10uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.12uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 0.12uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 0.12uM - 10uM 24H