General Information of Drug (ID: DMDKLB5)

Drug Name
Puromycin Drug Info
Synonyms
puromycin; Stylomycin; Puromycinum; Puromycine; Puromicina; UNII-4A6ZS6Q2CL; P-638; Stillomycin; CL 13900; 3123L; 4A6ZS6Q2CL; 3'-(L-alpha-Amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyladenosine; (S)-3'-((2-Amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3'-deoxy-N,N-dimethyladenosine; GNF-PF-2016; Puromycinum [INN-Latin]; Puromycine [INN-French]; Puromicina [INN-Spanish]; 9-{3-deoxy-3-[(O-methyl-L-tyrosyl)amino]-beta-D-xylofuranosyl}-N,N-dimethyl-9H-purin-6-amine; Bacterenomycin
Cross-matching ID
PubChem CID
439530
ChEBI ID
CHEMBL469912
CAS Number
CAS 53-79-2
VARIDT Drug ID
DR01525

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Protein processing in endoplasmic reticulum 2.76 0.00e+0 127/171 (74.27%) HSPA1A;HERPUD1;HSPA6;...
Legionellosis 2.59 0.00e+0 51/57 (89.47%) HSPA1A;HSPA6;HSPA8;...
TNF signaling pathway 2.30 0.00e+0 103/112 (91.96%) ATF4;TNFAIP3;CEBPB;...
Longevity regulating pathway 2.28 0.00e+0 90/151 (59.6%) HSPA1A;HSPA6;HSPA8;...
Lipid and atherosclerosis 2.24 0.00e+0 190/215 (88.37%) HSPA1A;HSPA6;DDIT3;...
Antigen processing and presentation 2.22 0.00e+0 60/78 (76.92%) HSPA1A;HSPA6;HSPA8;...
Measles 2.20 0.00e+0 133/139 (95.68%) HSPA1A;HSPA6;HSPA8;...
Ferroptosis 2.11 0.00e+0 36/41 (87.8%) HMOX1;SLC7A11;SLC3A2;...
NF-kappa B signaling pathway 2.03 0.00e+0 90/104 (86.54%) CXCL8;RELB;TNFAIP3;...
Prostate cancer 2.03 0.00e+0 93/97 (95.88%) ATF4;HSP90AA1;CDKN1A;...
Mitophagy 2.00 0.00e+0 56/68 (82.35%) ATF4;EIF2AK3;SQSTM1;...
IL-17 signaling pathway 1.96 0.00e+0 84/94 (89.36%) CXCL8;TNFAIP3;HSP90AA1;...
Osteoclast differentiation 1.94 0.00e+0 117/127 (92.13%) RELB;SQSTM1;JUN;...
Epstein-Barr virus infection 1.94 7.62e-4 189/202 (93.56%) RELB;TNFAIP3;GADD45A;...
Toxoplasmosis 1.93 7.12e-4 103/112 (91.96%) HSPA1A;HSPA6;HSPA8;...
Estrogen signaling pathway 1.92 2.67e-3 119/137 (86.86%) HSPA1A;HSPA6;HSPA8;...
Herpes simplex virus 1 infection 1.90 2.51e-3 165/498 (33.13%) EIF2AK3;HLA-DQA1;BIRC2;...
Autophagy 1.89 3.56e-3 113/169 (66.86%) DDIT4;EIF2AK3;IRS2;...
Kaposi sarcoma-associated herpesvirus infection 1.82 8.99e-3 172/193 (89.12%) CXCL8;CDKN1A;VEGFA;...
Rheumatoid arthritis 1.81 9.07e-3 78/93 (83.87%) CXCL8;VEGFA;HLA-DQA1;...
Apoptosis 1.80 9.15e-3 126/168 (75%) DDIT3;ATF4;PMAIP1;...
mRNA surveillance pathway 1.79 9.70e-3 71/98 (72.45%) NXF1;RNMT;PAPOLA;...
Spliceosome 1.79 9.75e-3 101/150 (67.33%) HSPA1A;HSPA6;HSPA8;...
Epithelial cell signaling in Helicobacter pylori infect... 1.77 1.16e-2 62/70 (88.57%) CXCL8;JUN;NFKBIA;...
NOD-like receptor signaling pathway 1.74 1.45e-2 145/181 (80.11%) CXCL8;TNFAIP3;HSP90AA1;...
Cocaine addiction 1.73 1.72e-2 42/49 (85.71%) ATF4;JUN;CREB3L2;...
Protein export 1.72 1.78e-2 17/23 (73.91%) HSPA5;SRPRA;SEC63;...
Tuberculosis 1.71 2.06e-2 159/180 (88.33%) CEBPG;HSPD1;HLA-DQA1;...
Hepatitis C 1.68 2.76e-2 139/157 (88.54%) EIF2AK3;CDKN1A;NFKBIA;...
MAPK signaling pathway 1.67 2.92e-2 272/294 (92.52%) HSPA1A;HSPA6;DDIT3;...
Galactose metabolism -1.59 4.75e-2 26/31 (83.87%) SI;GAA;GALE;...
Tyrosine metabolism -1.59 4.83e-2 30/36 (83.33%) ALDH3A1;MIF;FAH;...
Fat digestion and absorption -1.65 2.70e-2 35/43 (81.4%) GOT2;ACAT2;DGAT1;...
Thermogenesis -1.66 2.53e-2 173/232 (74.57%) CYC1;ADRB3;COX6B1;...
Oocyte meiosis -1.67 2.52e-2 90/129 (69.77%) PRKACB;CCNE1;PPP2R5C;...
Purine metabolism -1.67 2.55e-2 102/129 (79.07%) PGM1;CANT1;PAPSS1;...
Vitamin digestion and absorption -1.68 2.59e-2 17/24 (70.83%) APOA4;BTD;SCARB1;...
ECM-receptor interaction -1.68 2.58e-2 80/88 (90.91%) ITGB7;COL4A1;COL4A5;...
Morphine addiction -1.68 2.62e-2 80/91 (87.91%) GNAI2;GRK3;GNB3;...
Regulation of lipolysis in adipocytes -1.69 2.67e-2 52/55 (94.55%) AKT1;ADRB2;LIPE;...
Nucleotide excision repair -1.70 2.41e-2 40/47 (85.11%) CETN2;POLD3;POLD4;...
Mannose type O-glycan biosynthesis -1.70 2.45e-2 14/23 (60.87%) RXYLT1;POMT1;B4GALT3;...
Pyrimidine metabolism -1.72 2.21e-2 40/56 (71.43%) CTPS2;TK2;CANT1;...
Citrate cycle (TCA cycle) -1.73 1.93e-2 30/30 (100%) SDHA;ACLY;OGDH;...
Valine, leucine and isoleucine degradation -1.73 1.94e-2 42/48 (87.5%) ACAD8;ALDH9A1;ACADS;...
Mismatch repair -1.74 1.86e-2 22/23 (95.65%) RPA2;RFC4;MSH6;...
Glycolysis / Gluconeogenesis -1.75 2.06e-2 56/67 (83.58%) DLD;ALDOA;GAPDH;...
Base excision repair -1.87 5.80e-3 29/33 (87.88%) LIG3;APEX2;NTHL1;...
Glutathione metabolism -1.91 3.98e-3 43/57 (75.44%) RRM1;GPX1;GSTM1;...
Metabolism of xenobiotics by cytochrome P450 -1.92 3.09e-3 49/77 (63.64%) CYP2C9;CBR1;GSTM1;...
Pentose phosphate pathway -1.98 1.86e-3 25/30 (83.33%) G6PD;PGM1;PGLS;...
Drug metabolism -2.00 2.32e-3 78/151 (51.66%) MAOB;CYP2C9;TPMT;...
Retrograde endocannabinoid signaling -2.02 3.09e-3 118/148 (79.73%) NDUFS8;GNAI2;GNB3;...
Fatty acid degradation -2.04 4.64e-3 40/43 (93.02%) ALDH9A1;ACADS;ACAA1;...
DNA replication -2.15 0.00e+0 34/36 (94.44%) RPA2;RNASEH2B;RFC4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 4uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.37uM - 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H