Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMDMXKQ)

Drug Name	GSK1292263 Drug Info
Cross-matching ID	PubChem CID 24996872 ChEBI ID CHEMBL3187503 CAS Number CAS 1032823-75-8 TTD Drug ID D0S4II

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
TNF signaling pathway	2.17	0.00e+0	103/112 (91.96%)	CXCL2;CXCL3;CXCL1;...
Amoebiasis	2.13	0.00e+0	99/102 (97.06%)	CXCL2;CXCL8;CXCL3;...
IL-17 signaling pathway	2.09	0.00e+0	84/94 (89.36%)	CXCL2;CXCL8;CXCL3;...
Rheumatoid arthritis	2.08	0.00e+0	78/93 (83.87%)	CXCL2;CXCL8;CXCL3;...
Tryptophan metabolism	1.87	9.14e-3	35/42 (83.33%)	DLD;KYNU;ALDH3A2;...
Legionellosis	1.87	7.61e-3	51/57 (89.47%)	CXCL2;CXCL8;CXCL3;...
Focal adhesion	1.86	6.53e-3	180/201 (89.55%)	SPP1;SRC;VEGFA;...
Asthma	1.81	2.43e-2	25/31 (80.65%)	FCER1A;PRG2;HLA-DPA1;...
Viral protein interaction with cytokine and cytokine re...	1.80	2.41e-2	84/100 (84%)	CXCL2;CXCL8;CXCL3;...
Lysine degradation	1.79	2.97e-2	51/63 (80.95%)	PLOD2;DLD;ALDH3A2;...
Epithelial cell signaling in Helicobacter pylori infect...	1.77	3.11e-2	62/70 (88.57%)	CXCL2;CXCL8;CXCL3;...
Glycolysis / Gluconeogenesis	1.74	4.28e-2	56/67 (83.58%)	PGAM1;DLD;ENO2;...
AGE-RAGE signaling pathway in diabetic complications	1.74	4.22e-2	97/100 (97%)	CXCL8;IL6;VEGFA;...
Huntington disease	-1.70	4.46e-2	233/306 (76.14%)	DNALI1;DCTN5;POLR2L;...
Bile secretion	-1.71	4.48e-2	68/90 (75.56%)	ATP1A1;SLC5A1;ADCY9;...
Steroid hormone biosynthesis	-1.73	4.23e-2	43/61 (70.49%)	CYP2E1;HSD11B1;HSD17B7;...
Complement and coagulation cascades	-1.73	4.65e-2	76/85 (89.41%)	SERPINA1;F13B;SERPINF2;...
Linoleic acid metabolism	-1.80	3.02e-2	21/29 (72.41%)	PLA2G2A;CYP2C8;PLA2G4C;...
Parkinson disease	-1.88	4.23e-3	176/249 (70.68%)	COX4I1;PSMC3;GPR37;...
Metabolism of xenobiotics by cytochrome P450	-1.92	0.00e+0	49/77 (63.64%)	EPHX1;CYP2E1;HSD11B1;...
Retinol metabolism	-1.93	0.00e+0	41/68 (60.29%)	CYP3A5;UGT2B4;ALDH1A1;...
Oxidative phosphorylation	-1.93	0.00e+0	93/133 (69.92%)	COX6C;COX6B1;NDUFA5;...
Proteasome	-2.12	0.00e+0	44/46 (95.65%)	PSMD2;PSME4;PSME2;...
Mineral absorption	-2.19	0.00e+0	48/60 (80%)	ATP2B1;ATP2B2;ATOX1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H

MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.04uM - 10uM	24H

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.04uM - 10uM	24H