Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMDN4ZP)

Drug Name
Lixivaptan Drug Info
Synonyms
168079-32-1; VPA-985; WAY-VPA-985; UNII-8F5X4B082E; VPA985; CHEMBL49429; CRTX-080; VPA 985; 8F5X4B082E; N-[3-chloro-4-(6,11-dihydropyrrolo[2,1-c][1,4]benzodiazepine-5-carbonyl)phenyl]-5-fluoro-2-methylbenzamide; Lixar; Lixivaptan [USAN:INN]; Lixivaptan (USAN/INN); WAY VPA-985; Lixivaptan (VPA-985); AC1L59LM; WAY-VPA 985; GTPL2238; SCHEMBL1649340; DTXSID00168472; PPHTXRNHTVLQED-UHFFFAOYSA-N; ZINC600399; EX-A1129; BCP09167; BDBM50065115; AKOS022181388; AN-1842; CS-7512; API0009250; NCGC00485402-01; VPA985; BF-Derm1
Cross-matching ID
PubChem CID
172997
ChEBI ID
CHEMBL49429
CAS Number
CAS 168079-32-1
TTD Drug ID
D07EEN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Retinol metabolism 2.32 0.00e+0 41/68 (60.29%) ALDH1A1;UGT2B4;ALDH1A2;...
Glycine, serine and threonine metabolism 2.16 0.00e+0 31/40 (77.5%) DLD;PSAT1;ALDH7A1;...
Tyrosine metabolism 2.15 0.00e+0 30/36 (83.33%) AOX1;TYR;TYRP1;...
Valine, leucine and isoleucine degradation 2.13 0.00e+0 42/48 (87.5%) HMGCS1;DLD;ALDH6A1;...
Steroid biosynthesis 1.96 1.63e-3 19/20 (95%) MSMO1;FDFT1;NSDHL;...
Glyoxylate and dicarboxylate metabolism 1.95 2.71e-3 23/30 (76.67%) DLD;ACAT2;PCCB;...
Butanoate metabolism 1.89 6.97e-3 23/28 (82.14%) HMGCS1;ACAT2;BDH2;...
Sulfur metabolism 1.86 8.13e-3 9/10 (90%) PAPSS2;TST;SELENBP1;...
Drug metabolism 1.82 1.08e-2 78/151 (51.66%) GSTA1;CES1;UGT2B4;...
Bile secretion 1.81 1.14e-2 68/90 (75.56%) ABCG2;UGT2B4;PRKACB;...
Phenylalanine metabolism 1.77 1.48e-2 14/17 (82.35%) GOT1;HPD;MAOA;...
Pancreatic secretion 1.76 1.63e-2 87/102 (85.29%) CLCA4;GNAQ;SLC12A2;...
Nitrogen metabolism 1.75 1.63e-2 16/17 (94.12%) GLUL;CA2;GLUD1;...
Propanoate metabolism 1.75 1.51e-2 30/34 (88.24%) DLD;ALDH6A1;ACAT2;...
Alanine, aspartate and glutamate metabolism 1.72 1.52e-2 27/37 (72.97%) ALDH5A1;GLUL;GOT1;...
Arginine biosynthesis 1.72 1.47e-2 17/22 (77.27%) GLUL;GOT1;ASS1;...
Tryptophan metabolism 1.68 2.58e-2 35/42 (83.33%) DLD;ALDH7A1;KYNU;...
Collecting duct acid secretion 1.68 2.67e-2 22/27 (81.48%) ATP6V1D;ATP6V1C1;ATP6V0D1;...
Ovarian steroidogenesis 1.64 3.68e-2 41/51 (80.39%) INSR;IGF1;PRKACB;...
Protein digestion and absorption 1.62 4.19e-2 78/103 (75.73%) COL14A1;COL4A5;COL16A1;...
Synthesis and degradation of ketone bodies 1.62 4.14e-2 9/10 (90%) HMGCS1;ACAT2;BDH2;...
Metabolism of xenobiotics by cytochrome P450 1.59 4.88e-2 49/77 (63.64%) GSTA1;UGT2B4;UGT2B28;...
DNA replication -2.02 5.97e-3 34/36 (94.44%) MCM7;POLE2;POLD2;...
Proteasome -2.14 0.00e+0 44/46 (95.65%) PSMA3;PSMB7;PSMB6;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H