Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMDNHEP)

Drug Name
QUINPIROLE Drug Info
Synonyms
Quinpirolum; Quinpirol; Quinpirole [INN]; Quinpirolum [Latin]; Quinpirol [Spanish]; 80373-22-4; UNII-20OP60125T; CHEBI:75401; LY 156258; CHEMBL240773; (4aR-trans)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo(3,4-g)quinoline; 20OP60125T; 1H-Pyrazolo(3,4-g)quinoline, 4,4a,5,6,7,8,8a,9-octahydro-5-propyl-, (4aR-trans)-; (4aR,8aR)-5-propyl-1,4,4a,6,7,8,8a,9-octahydropyrido[2,3-f]indazole; (4aR,8aR)-5-propyl-1,4,4a,6,7,8,8a,9-octahydropyrazolo[3,4-g]quinoline
Cross-matching ID
PubChem CID
54562
ChEBI ID
CHEMBL240773
CAS Number
CAS 80373-22-4
TTD Drug ID
D0H2WQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Dilated cardiomyopathy 1.91 2.15e-2 86/96 (89.58%) TNNC1;PRKACB;IGF1;...
Hypertrophic cardiomyopathy 1.86 4.29e-2 81/90 (90%) TNNC1;IGF1;MYL2;...
Cardiac muscle contraction 1.84 3.22e-2 64/87 (73.56%) TNNC1;MYL2;ATP1B3;...
Regulation of lipolysis in adipocytes 1.80 3.49e-2 52/55 (94.55%) PRKACB;FABP4;CGA;...
Chemokine signaling pathway 1.77 3.65e-2 163/192 (84.9%) CXCL14;PAK1;PF4;...
cGMP-PKG signaling pathway 1.76 3.58e-2 145/167 (86.83%) NFATC3;PLCB3;ADRA2A;...
Osteoclast differentiation -1.84 3.69e-2 117/127 (92.13%) TAB1;FCGR2B;LILRA2;...
Glycine, serine and threonine metabolism -1.90 4.61e-2 31/40 (77.5%) PSPH;SHMT2;GLDC;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 15uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H