Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMDNJHG)

• Drug Name: Aztreonam Drug Info
• Synonyms: Azactam; Primbactam; Azactam (TN); SQ-26776; Monobactam, SQ 26776, Squibb 26776, Aztreonam; [2S-[2alpha,3beta(Z)]]-2-[[[1-(2-Amino-4-thiazolyl)-2-[(2-methyl-4-oxo-1-sulfo-3-azetidinyl)amino]-2-oxoethylidene]amino]oxy]-2-methylpropanoic acid; 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-{[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino}-2-oxoethylidene]amino}oxy)-2-methylpropanoic acid; 2-[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino]-2-oxoethylidene]amino]oxy-2-methylpropanoic acid
• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 5742832
  ChEBI ID: CHEMBL161680
  CAS Number: CAS 78110-38-0
  TTD Drug ID: D0F2XV
  INTEDE Drug ID: DR0169
  ACDINA Drug ID: D00857

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Mismatch repair	2.12	0.00e+0	22/23 (95.65%)	PCNA;RFC5;MLH1;...
DNA replication	1.93	3.17e-3	34/36 (94.44%)	PCNA;RFC5;RFC3;...
Nucleotide excision repair	1.77	1.69e-2	40/47 (85.11%)	PCNA;RFC5;RFC3;...
Citrate cycle (TCA cycle)	1.72	3.17e-2	30/30 (100%)	DLD;IDH2;FH;...
Salivary secretion	-1.73	4.47e-2	76/93 (81.72%)	CST5;ADCY9;ATP2B2;...
Adrenergic signaling in cardiomyocytes	-1.77	2.87e-2	130/150 (86.67%)	ADRA1D;AKT2;PPP2R3A;...
Melanoma	-1.77	3.03e-2	68/72 (94.44%)	E2F3;MAPK3;ARAF;...
Calcium signaling pathway	-1.79	2.22e-2	213/240 (88.75%)	FGF17;FGF2;TRDN;...
PPAR signaling pathway	-1.85	1.95e-2	66/74 (89.19%)	MMP1;AQP7;SLC27A2;...
Steroid biosynthesis	-1.85	2.28e-2	19/20 (95%)	LIPA;EBP;FDFT1;...
Cholesterol metabolism	-1.90	1.64e-2	44/50 (88%)	SOAT2;LIPC;APOE;...
Dilated cardiomyopathy	-1.94	1.02e-2	86/96 (89.58%)	SGCA;ADCY9;DES;...
Pentose phosphate pathway	-2.06	0.00e+0	25/30 (83.33%)	RGN;PGLS;ALDOB;...
Hypertrophic cardiomyopathy	-2.18	0.00e+0	81/90 (90%)	DES;CACNG1;ITGA3;...
Cardiac muscle contraction	-2.24	0.00e+0	64/87 (73.56%)	TRDN;COX7A2L;CACNG1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	4uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	8uM	72H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	24H	Show ▼