Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMDNUM5)

Drug Name
NU-7432 Drug Info
Synonyms NU-7441
Cross-matching ID
PubChem CID
11327430
ChEBI ID
CHEMBL91361
CAS Number
CAS 503468-95-9
TTD Drug ID
D0Y3OO

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.61 0.00e+0 19/20 (95%) MSMO1;FDFT1;SQLE;...
Metabolism of xenobiotics by cytochrome P450 1.88 8.41e-3 49/77 (63.64%) GSTM3;AKR7A2;GSTA4;...
Tuberculosis -1.72 4.96e-2 159/180 (88.33%) MAPK11;TGFB3;HLA-DQB1;...
Pertussis -1.85 1.51e-2 64/76 (84.21%) IL1B;RELA;JUN;...
Intestinal immune network for IgA production -1.87 1.38e-2 38/48 (79.17%) ICOS;HLA-DQB1;TGFB1;...
Viral protein interaction with cytokine and cytokine re... -1.89 1.01e-2 84/100 (84%) TNFRSF10D;CCL19;CCL13;...
Systemic lupus erythematosus -1.91 9.65e-3 45/135 (33.33%) GRIN2A;CD80;CTSG;...
Rheumatoid arthritis -1.94 9.05e-3 78/93 (83.87%) TGFB3;CXCL3;HLA-DQB1;...
Asthma -1.96 8.04e-3 25/31 (80.65%) IL9;HLA-DQB1;HLA-DPB1;...
Hematopoietic cell lineage -2.04 6.03e-3 90/99 (90.91%) CD1B;CD1A;CD8A;...
Staphylococcus aureus infection -2.11 0.00e+0 72/95 (75.79%) FCGR2B;KRT9;DEFB4A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H