Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMDO279)

• Drug Name: Phenprocoumon Drug Info
• Synonyms: Falithiom; Falithrom; Fencumar; Fenprocoumona; Fenprocumon; Fenprocumone; Liquamar; Marcoumar; Marcumar; Marcuphen; Phenprocoumalol; Phenprocoumarol; Phenprocoumarole; Phenprocoumone; Phenprocoumonum; Phenprocumone; Phenprocumonum; Phenprogramma; Phenylpropylhydroxycumarinum; Fenprocumone [DCIT]; Hexal Brand of Phenprocoumon; Roche Brand of Phenprocoumon; Worwag Brand of Phenprocoumon; U29342; Falithrom (TN); Fenprocoumona [INN-Spanish]; Liquamar (TN); Marcoumar (TN); Marcumar (TN); Phenprocoumone [INN-French]; Phenprocoumonum [INN-Latin]; Ro 1-4849; Phenprocoumon (USAN/INN); Phenprocoumon [USAN:INN:BAN]; 2-hydroxy-3-(1-phenylpropyl)chromen-4-one; 3-(1'-Phenyl-propyl)-4-oxycoumarin; 3-(1'-Phenyl-propyl)-4-oxycoumarin [German]; 3-(1-Phenylpropyl)-4-hydroxycoumarin; 3-(alpha-Ethylbenzyl)-4-hydroxycoumarin; 3-(alpha-Phenylpropyl)-4-hydroxycoumarin; 4-Hydroxy-3-(1-phenylpropyl)-2H-1-benzopyran-2-one; 4-Hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one
• Therapeutic Class: Anticoagulants
• Cross-matching ID:
  PubChem CID: 54680692
  ChEBI ID: CHEMBL1465
  CAS Number: CAS 435-97-2
  TTD Drug ID: D0QV5T
  VARIDT Drug ID: DR01279
  INTEDE Drug ID: DR1279

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Kaposi sarcoma-associated herpesvirus infection	-1.71	3.99e-2	172/193 (89.12%)	MAP2K1;IKBKB;ITPR1;...
Ferroptosis	-1.72	3.85e-2	36/41 (87.8%)	MAP1LC3B;FTL;PCBP1;...
NF-kappa B signaling pathway	-1.74	3.50e-2	90/104 (86.54%)	RELB;CFLAR;BIRC3;...
Galactose metabolism	-1.74	3.79e-2	26/31 (83.87%)	HKDC1;G6PC3;GALK1;...
Non-small cell lung cancer	-1.74	4.03e-2	70/72 (97.22%)	MAP2K2;RASSF1;RAF1;...
Apoptosis	-1.74	4.31e-2	126/168 (75%)	PARP4;CFLAR;MAP2K1;...
Pancreatic cancer	-1.78	3.33e-2	75/76 (98.68%)	MAP2K1;IKBKB;BCL2L1;...
Synaptic vesicle cycle	-1.79	3.59e-2	63/78 (80.77%)	SLC17A7;ATP6V1F;ATP6V1E1;...
TNF signaling pathway	-1.81	3.59e-2	103/112 (91.96%)	MAP2K3;CFLAR;MAP2K1;...
Bladder cancer	-1.82	3.19e-2	40/41 (97.56%)	MAP2K1;MDM2;MAP2K2;...
Epithelial cell signaling in Helicobacter pylori infect...	-1.87	1.68e-2	62/70 (88.57%)	ATP6V1F;ATP6V1E1;IKBKB;...
Cholesterol metabolism	-1.89	1.20e-2	44/50 (88%)	APOA1;MYLIP;TSPO;...
Amino sugar and nucleotide sugar metabolism	-1.90	1.60e-2	38/48 (79.17%)	PMM2;PMM1;RENBP;...
Rheumatoid arthritis	-2.08	5.99e-3	78/93 (83.87%)	CD80;ICAM1;TCIRG1;...
IL-17 signaling pathway	-2.12	0.00e+0	84/94 (89.36%)	RELA;NFKBIA;MAPK6;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 2.22uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 0.74uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼