Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMDOZPU)

Drug Name
PK 11195 Drug Info
Synonyms
1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide; 85532-75-8; PK-11195; PK11195; RP 52028; BRN 4264456; CHEBI:73290; N-sec-butyl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide; N-butan-2-yl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide; N-(butan-2-yl)-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide; 3-Isoquinolinecarboxamide, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-; SMR000058427; SR-01000076240; Biomol-NT_000287; AC1L1B9T; DSSTox_RID_79625; Interferon alfa (IFN-alpha)
Cross-matching ID
PubChem CID
1345
ChEBI ID
CHEMBL481537
CAS Number
CAS 85532-75-8
TTD Drug ID
D0VN4K

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis -1.69 3.71e-2 19/20 (95%) TM7SF2;SC5D;LIPA;...
Peroxisome -1.70 3.62e-2 72/82 (87.8%) MPV17;PEX5;PEX12;...
Collecting duct acid secretion -1.71 3.51e-2 22/27 (81.48%) ATP6V1C1;CA2;ATP6V1D;...
Complement and coagulation cascades -1.72 3.37e-2 76/85 (89.41%) FGG;FGB;SERPIND1;...
Vibrio cholerae infection -1.74 3.32e-2 44/50 (88%) SEC61B;ATP6V1C1;KCNQ1;...
Fatty acid degradation -1.76 3.01e-2 40/43 (93.02%) ECI2;ACADS;CPT1A;...
Leishmaniasis -1.80 2.20e-2 67/77 (87.01%) HLA-DMB;ELK1;TNF;...
PPAR signaling pathway -1.84 1.93e-2 66/74 (89.19%) PPARA;FADS2;SLC27A5;...
Staphylococcus aureus infection -1.86 2.12e-2 72/95 (75.79%) FPR3;HLA-DMB;FPR2;...
Legionellosis -1.93 9.64e-3 51/57 (89.47%) TNF;TLR5;CR1;...
Malaria -2.01 3.21e-3 44/50 (88%) ICAM1;SDC1;TNF;...
Oxidative phosphorylation -2.05 4.82e-3 93/133 (69.92%) ATP5MF;COX17;ATP6V1C1;...
Phagosome -2.29 0.00e+0 118/152 (77.63%) DYNC1LI1;SEC61B;ATP6V1C1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 150uM 6H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 150uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 150uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 150uM 6H
MDST8 CVCL_1400 Homo sapiens 150uM 6H
NCI-H508 CVCL_1561 Homo sapiens 150uM 6H
SNU-1040 CVCL_5001 Homo sapiens 150uM 6H
SNU-C4 CVCL_5008 Homo sapiens 150uM 6H
SNU-C5 CVCL_5009 Homo sapiens 150uM 6H
SW480 CVCL_0546 Homo sapiens 150uM 6H
SW620 CVCL_0547 Homo sapiens 150uM 6H
SW948 CVCL_0550 Homo sapiens 150uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 150uM 6H
HT115 CVCL_1294 Homo sapiens 150uM 6H
RKO CVCL_0504 Homo sapiens 150uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 150uM 6H
SNG-M CVCL_1707 Homo sapiens 150uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 150uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 150uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM - 150uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 150uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 150uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 150uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 150uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 150uM 6H
T3M-10 CVCL_1729 Homo sapiens 150uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 150uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 150uM 6H
HCC515 CVCL_5134 Homo sapiens 10uM - 150uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 150uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 150uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 150uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 150uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 150uM 6H
OV7 CVCL_1623 Homo sapiens 150uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 150uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 150uM 6H
RMUG-S CVCL_1666 Homo sapiens 150uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 150uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 150uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 150uM 6H
PL-21 CVCL_2161 Homo sapiens 150uM 6H
SKM-1 CVCL_0010 Homo sapiens 150uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 150uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 150uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM - 150uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 150uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 150uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 150uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 150uM 6H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H