Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMDPM7R)

• Drug Name: Y-25130 Drug Info
• Synonyms: Azasetron; Nazasetron; Azasetron [INN]; C17H20ClN3O3; 123039-99-6; WUKZPHOXUVCQOR-UHFFFAOYSA-N; Azasetron (INN); 6-Chloro-4-methyl-3-oxo-N-(quinuclidin-3-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide; NCGC00024563-02; DSSTox_RID_81029; DSSTox_CID_25651; DSSTox_GSID_45651; (- )-6-Chloro-3,4-dihydro-4-methyl-3-oxo-N-3-quinuclidinyl-2H-1,4-benzoxazine-8-carboxamide; N-(1-azabicyclo[2.2.2]octan-3-yl)-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide
• Cross-matching ID:
  PubChem CID: 2264
  ChEBI ID: CHEMBL91712
  CAS Number: CAS 123040-69-7
  TTD Drug ID: D00SVU
  VARIDT Drug ID: DR01499

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Pyrimidine metabolism	2.16	0.00e+0	40/56 (71.43%)	CANT1;NME4;NT5E;...
Purine metabolism	2.05	0.00e+0	102/129 (79.07%)	CANT1;NME4;NT5E;...
Complement and coagulation cascades	2.01	5.97e-3	76/85 (89.41%)	C7;CFI;C4BPA;...
Primary bile acid biosynthesis	1.94	6.71e-3	15/17 (88.24%)	SLC27A5;ACOX2;AMACR;...
Drug metabolism	1.81	1.97e-2	78/151 (51.66%)	NME4;CYP3A5;GSTO1;...
Mineral absorption	-1.87	1.93e-2	48/60 (80%)	FTL;FTH1;VDR;...
Cytokine-cytokine receptor interaction	-1.88	1.47e-2	246/295 (83.39%)	IL12RB2;GH1;IL17B;...
Viral protein interaction with cytokine and cytokine re...	-1.89	2.21e-2	84/100 (84%)	CX3CR1;IL10RA;CXCL11;...
Rheumatoid arthritis	-2.36	0.00e+0	78/93 (83.87%)	HLA-DOB;ATP6V0D1;CXCL12;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼